- Featured Product
- KD/KO Validated
CoraLite®555-conjugated G3BP2 Polyclonal antibody
G3BP2 Polyclonal Antibody for IF
Host / Isotype
Rabbit / IgG
CoraLite®555 Fluorescent Dye
Cat no : CL555-16276
|Positive IF detected in
|sodium arsenite treated HeLa cells
|IF : 1:50-1:500
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
The immunogen of CL555-16276 is G3BP2 Fusion Protein expressed in E. coli.
|Host / Isotype
|Rabbit / IgG
|G3BP2 fusion protein Ag9355
|GTPase activating protein (SH3 domain) binding protein 2
|Calculated molecular weight
|482aa,54 kDa; 449aa,51 kDa
|Observed molecular weight
|GenBank accession number
|Gene ID (NCBI)
|CoraLite®555 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|557 nm / 570nm
|Antigen affinity purification
|PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
|Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
Stress granules (SGs) are cytoplasmic mRNA-protein condensates formed in response to cellular stressors, such as oxidative stress, ultraviolet radiation, and viral infection (1). The Ras-GTPase-activating protein-binding proteins (G3BPs), consisting of G3BP1 and G3BP2, are key nucleating factors essential for SG formation. They function to protect RNAs from harmful conditions. G3BP2 is mainly distributed in the cytoplasm and participates in the formation of stress granules, cell differentiation, proliferation, and signal transduction. Accumulating evidence has demonstrated that aberrant expression of G3BP2 contributes to cancer initiation and progression, such as high expression of G3BP2 increasing cell stemness, metastasis and chemoresistance in breast cancer.