GLP1R Monoclonal antibody

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  IF Staining of rat pancreas using 60931-1-Ig

  Immunofluorescent analysis of un-fixed rat pancreas using GLP1R antibody (60931-1-Ig) at dilution of 1:3498 and RGAU011.

• 

  IF Staining of rat pancreas using 60931-1-Ig

  Immunofluorescent analysis of un-fixed rat pancreas using GLP1R antibody (60931-1-Ig) at dilution of 1:1749 and RGAU011.

GLP1R Monoclonal Antibody for IF/ICC, ELISA

Cat No. 60931-1-Ig

Clone No.1A4G5

Host / Isotype

Mouse / IgG1

Reactivity

human, rat

Applications

IF/ICC, ELISA

Synonyms

GLP 1 R, GLP 1 receptor, GLP 1R, GLP-1 receptor, GLP-1R

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Tested Applications

• Positive IF/ICC detected in: rat pancreas

Recommended dilution

• Immunofluorescence (IF)/ICC: IF/ICC : 1:1749-1:6996

It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Sample-dependent, Check data in validation data gallery.

Product Information

60931-1-Ig targets GLP1R in IF/ICC, ELISA applications and shows reactivity with human, rat samples.

• Tested Reactivity: human, rat
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: GLP1R fusion protein Ag23529
• Full Name: glucagon-like peptide 1 receptor
• Calculated Molecular Weight: 463 aa, 53 kDa
• GenBank Accession Number: BC112126
• Gene Symbol: GLP1R
• Gene ID (NCBI): 2740
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein G Magarose purification
• UNIPROT ID: P43220
• Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
• Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage. 20ul sizes contain 0.1% BSA.

Background Information

GLP1R (glucagon-like peptide-1 receptor) is a G protein-coupled receptor belonging to the secretin receptor superfamily, also known as class B (PMID:34911028). GLP1R is widely distributed in pancreatic islets, muscles, the gastrointestinal tract, the lung, liver, pancreas, and other tissues or organs (PMID:35989517). Moreover, GLP1R agonist has been reported to induce autophagy of EC (Endometrial carcinoma) cells, and high GLP1R expression may be associated with good prognosis of EC patients, suggesting that GLP1R is likely to participate in the progression of EC (PMID:29907137). Moreover, regarding the molecular weight of GLP1R, research shows that the bands at ~50 kDa and ~100 kDa belong to the monomer and dimer states of GLP1R (PMID: 28609478).