HIC2 Polyclonal antibody, PBS Only

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• HIC2 Polyclonal antibody, PBS Only (22788-1-PBS)

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  WB analysis of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

  Jurkat cells were subjected to SDS PAGE followed by western blot with 22788-1-AP (HIC2 Antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

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  IP experiment of Jurkat using 22788-1-AP (same clone as 22788-1-PBS)

  IP result of anti-HIC2 (IP:22788-1-AP, 4ug; Detection:22788-1-AP 1:300) with Jurkat cells lysate 2400ug. This data was developed using the same antibody clone with 22788-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

HIC2 Polyclonal Antibody for WB, IP, Indirect ELISA

Cat No. 22788-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IP, Indirect ELISA

Synonyms

Hic 2, Hic 3, HIC1-related gene on chromosome 22 protein, Hic-2, Hic-3

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Product Information

22788-1-PBS targets HIC2 in WB, IP, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag18789

  Product name: Recombinant human HIC2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 161-430 aa of BC094787

  Sequence: RSQRLSTASVIQARYQGLVDGRKGAHAPQELPQAKGSDDELFLGGSNQDSVQGLGRAVCPAGGEAGLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVANSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREAGPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGHASAHYMYRQE

• Full Name: hypermethylated in cancer 2
• Calculated Molecular Weight: 615 aa, 66 kDa
• Observed Molecular Weight: 66 kDa
• GenBank Accession Number: BC094787
• Gene Symbol: HIC2
• Gene ID (NCBI): 23119
• RRID: AB_2879169
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q96JB3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

HIC2 (hypermethylated in cancer 2) is a transcription factor related to the tumour suppressor HIC1, required for normal cardiac development and lost in distal variants of 22q11 Deletion Syndrome (PMID: 29061339). HIC2 is also a POK family protein, and the amino acid sequence of its BTB/POZ and zinc-finger domains are similar to those of HIC1(PMID: 31127867). Studies have shown that HIC2 plays a role in suppressing fetal genes for normal development of the heart and circulatory system, in embryogenesis (PMID: 24748541).