IL-22 Recombinant monoclonal antibody, PBS Only

• 

  WB analysis using 82766-15-RR (same clone as 82766-15-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

• 

  WB analysis of Recombinant protein using 82766-15-RR (same clone as 82766-15-PBS)

  Recombinant protein were subjected to SDS PAGE followed by western blot with 82766-15-RR (IL22 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 82766-15-PBS in a different storage buffer formulation.

IL-22 Uni-rAb^® Recombinant Antibody for WB, Indirect ELISA

Cat No. 82766-15-PBS

Clone No.250428B5

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

IL22, Cytokine Zcyto18, IL 21, IL 22, IL D110

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Product Information

82766-15-PBS targets IL-22 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  Recombinant protein

• Full Name: interleukin 22
• Observed Molecular Weight: 20 kDa
• GenBank Accession Number: BC066263
• Gene Symbol: IL-22
• Gene ID (NCBI): 50616
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q9GZX6
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020).