MIPOL1 Polyclonal antibody, PBS Only

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• MIPOL1 Polyclonal antibody, PBS Only (14158-1-PBS)

MIPOL1 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 14158-1-PBS Copied!

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Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

mirror image polydactyly 1, Mirror-image polydactyly gene 1 protein

• 

  WB analysis using 14158-1-AP (same clone as 14158-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 14158-1-AP (MIPOL1 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 14158-1-PBS in a different storage buffer formulation.

  This validation data has been generated in-house and reviewed by Proteintech scientists. Find out more on our antibody validation policy

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Product Information

14158-1-PBS targets MIPOL1 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag5340

  Product name: Recombinant human MIPOL1 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1-261 aa of BC035870

  Sequence: MSRLQLAIEERDEAIARAKHMEMSLKVLENINPEENDMTLQELLNRINNADTGIAIQKNGAIIVDRIYKTKECKMRITAEEMSALIEERDAALSKCKRLEQELHHVKEQNQTSANNMRHLTAENNQERALKAKLLSMQQARETAVQQYKKLEEEIQTLRVYYSLHKSLSQEENLKDQFNYTLSTYEEALKNRENIVSITQQQNEELATQLQQALTERANMELQLQHAREASQVANEKVQKLERLVDVLRKKVGTGTMRTVI

• Full Name: mirror-image polydactyly 1
• Calculated Molecular Weight: 442 aa, 52 kDa
• Observed Molecular Weight: 52 kDa
• GenBank Accession Number: BC035870
• Gene Symbol: MIPOL1
• Gene ID (NCBI): 145282
• RRID: AB_2141930
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q8TD10
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

MIPOL1 (also named CCDC193) encodes a nuclear coiled-coil protein. Germline MIPOL1 variants cause Laurin‑Sandrow syndrome characterized by mirror-image polydactyly. It acts as a candidate tumor suppressor in nasopharyngeal carcinoma. Downregulation of MIPOL1 activates AKT/FAK signaling, elevates angiogenic cytokines, and promotes cancer invasion and metastasis. Restoration of wild-type MIPOL1 enhances RhoB activity and suppresses tumor progression both in vitro and in xenograft mouse models. (PMID: 31609475)