MSL2 Polyclonal antibody, PBS Only

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• MSL2 Polyclonal antibody, PBS Only (23601-1-PBS)

• 

  WB analysis using 23601-1-AP (same clone as 23601-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 23601-1-AP (MSL2 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 23601-1-PBS in a different storage buffer formulation.

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  IF Staining of A431 using 23601-1-AP (same clone as 23601-1-PBS)

  Immunofluorescent analysis of (4% PFA) fixed A431 cells using MSL2 antibody (23601-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-phalloidin (red). This data was developed using the same antibody clone with 23601-1-PBS in a different storage buffer formulation.

MSL2 Polyclonal Antibody for WB, IF/ICC, Indirect ELISA

Cat No. 23601-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF/ICC, Indirect ELISA

Synonyms

MS L2, MSL 2, MSL2 like 1, MSL2L1, RNF184

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Product Information

23601-1-PBS targets MSL2 in WB, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag18727

  Product name: Recombinant human MSL2 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 228-577 aa of BC093790

  Sequence: TEDLSDSLPPVCDTVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKIAKLNRKRSRSESDSEKVQPLPISTIIRGPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSHSKTKPGILKKDKAVKEKIPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQRCPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRLTLGINVTSIAVRNASTSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC

• Full Name: male-specific lethal 2 homolog (Drosophila)
• Calculated Molecular Weight: 577 aa, 63 kDa
• Observed Molecular Weight: 70-75 kDa
• GenBank Accession Number: BC093790
• Gene Symbol: MSL2
• Gene ID (NCBI): 55167
• RRID: AB_3742087
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• UNIPROT ID: Q9HCI7
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

In mammals, MSL2 participates in histone H2B ubiquitination (H2Bub1) via the MSL complex, regulating transcription and chromatin remodeling. It is essential for embryonic development and has been implicated in cancer progression. MSL2's dysfunction is linked to developmental defects and oncogenesis, highlighting its critical role in gene regulation. (PMID: 30669413; PMID: 34899909)