Recombinant Mouse MST1R protein (rFc Tag) (HPLC verified)

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• Recombinant Mouse MST1R protein (rFc Tag) (HPLC verified) (Eg2647)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg2647

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Validation Data Gallery

• 

  Purity of Recombinant Mouse MST1R was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

• 

  The purity of Mouse MST1R was greater than 90% as determined by SEC-HPLC.

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Product Information

• Purity: >90 %, SDS-PAGE; >90 %, SEC-HPLC
• Endotoxin: <0.1 EU/μg protein, LAL method
• Activity:

  Not tested

• Expression: CHO-derived Mouse MST1R protein Thr25-Arg960 (Accession# Q62190-1) with a rabbit IgG Fc tag at the C-terminus.
• GeneID: 19882
• Accession: Q62190-1
• PredictedSize: 127.2 kDa
• SDS-PAGE: 28-32 kDa, 90-120 kDa and 200-220 kDa, reducing (R) conditions
• Formulation: Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
• Reconstitution: Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
• Storage Conditions:
  It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

Mst1r (macrophage-stimulating 1 receptor), encodes a cell surface receptor for macrophage-stimulating 1 (MST1, also known as MSP) with tyrosine kinase activity. Mst1r is critical for innate immunity and plays an important role for host defense against viral infection. The upregulation of MST1R tyrosine kinase expression is a molecular event of particular interest in many epithelial neoplasms, as it can mediate oncogenic phenotypes and addiction to KRAS signaling.

References:

1. Dai W, et al. (2016). Proc Natl Acad Sci U S A. Mar 22;113(12):3317-22.
2. Babicky, M. L., et al. (2019). Oncogene. Jul;38(28):5599-5611.
3. Wang W, et al. (2024). Cell Biosci. Aug 29;14(1):109.