CoraLite®594-conjugated NRG1 Monoclonal antibody

NRG1 Monoclonal Antibody for IF

Host / Isotype

Mouse / IgG1

Reactivity

Human, pig, mouse, rat

Applications

IF

Conjugate

CoraLite®594 Fluorescent Dye

CloneNo.

2C6D12

Cat no : CL594-66492

Synonyms

ARIA, GGF, GGF2, Glial growth factor, Heregulin, HGL, HRG, HRG1, HRGA, NDF, Neu differentiation factor, neuregulin 1, NRG1, Pro NRG1, SMDF

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Validation Data Gallery

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  IF Staining of MCF-7 using CL594-66492

  Immunofluorescent analysis of (-20°C Ethanol) fixed MCF-7 cells using CL594-66492 (NRG1 antibody) at dilution of 1:100.

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Tested Applications

• Positive IF detected in: MCF-7 cells

For other applications, we recommend the unconjugated version of this antibody, 66492-1-Ig

Recommended dilution

• Immunofluorescence (IF): IF : 1:50-1:500

Sample-dependent, check data in validation data gallery

Product Information

CL594-66492 targets NRG1 in IF applications and shows reactivity with Human, pig, mouse, rat samples.

• Tested Reactivity: Human, pig, mouse, rat
• Host / Isotype: Mouse / IgG1
• Class: Monoclonal
• Type: Antibody
• Immunogen: NRG1 fusion protein Ag0803
• Full Name: neuregulin 1
• Calculated molecular weight: 32 kDa
• Observed molecular weight: 70 kDa
• GenBank accession number: BC007675
• Gene symbol: NRG1
• Gene ID (NCBI): 3084
• Conjugate: CoraLite®594 Fluorescent Dye
• Excitation/Emission maxima wavelengths: 593 nm/614 nm
• Form: Liquid
• Purification Method: Protein G purification
• Storage Buffer: PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
• Storage Conditions: Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Background Information

Neuregulin 1 (NRG1) is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. NRG1 and its receptor ErbB tyrosine kinase are expressed not only in the developing nervous system, but also in the adult brain.