Validation Data Gallery
|Positive WB detected in||human placenta tissue, human plasma, fetal human brain tissue, pig brain tissue|
|Positive IF detected in||SH-SY5Y cells, human embronic stem cells|
|Positive FC detected in||SH-SY5Y cells|
|Western Blot (WB)||WB : 1:1000-1:6000|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
60067-1-Ig targets Neuropilin 1 in WB, IF, FC, ELISA applications and shows reactivity with human, pig samples.
|Tested Reactivity||human, pig|
|Cited Reactivity||human, mouse, Xenopus|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Neuropilin 1 fusion protein Ag0931|
|Full Name||neuropilin 1|
|Calculated molecular weight||103 kDa|
|Observed molecular weight||130 kDa|
|GenBank accession number||BC007737|
|Gene ID (NCBI)||8829|
|Purification Method||Caprylic acid/ammonium sulfate precipitation|
|Storage Buffer||PBS with 0.1% sodium azide and 50% glycerol pH 7.3.|
|Storage Conditions||Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.|
Neuropilin-1 (NRP1) is a a 130-140 kDa transmembrane glycoprotein expressed by endothelial, dendritic, and regulatory T cells, as well as several other normal cell types and malignant tumor cells. NRP1 was first identified as a semaphorin (SEMA) receptor, involved in axonal guidance in embryonic development. NRP1 was also shown to act as a receptor for vascular endothelial growth factor (VEGF) and a promoter of angiogenesis through its interaction with VEGF-A165 (and other VEGFs) and the receptor tyrosine kinase (RTK) VEGF-R2. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.
RNA binding protein PUM2 promotes the stemness of breast cancer cells via competitively binding to neuropilin-1 (NRP-1) mRNA with miR-376a.
Am J Med Genet A
NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot.
Cell Death Dis
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
Mol Cell Biochem
miR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1.
Exp Eye Res
Expression of axon guidance ligands and their receptors in the cornea and trigeminal ganglia and their recovery after corneal epithelium injury.
Dual Receptor Targeting Cell Penetrating Peptide Modified Liposome for Glioma and Breast Cancer Postoperative Recurrence Therapy.