Neuroserpin Recombinant antibody, PBS Only

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  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (SERPINI1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (Neuroserpin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 85923-1-RR (same clone as 85923-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 85923-1-RR (SERPINI1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

• 

  IHC staining of mouse brain using 85923-1-RR (same clone as 85923-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 85923-1-RR (Neuroserpin antibody) at dilution of 1:400 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 85923-1-PBS in a different storage buffer formulation.

Neuroserpin Uni-rAb^TM Recombinant Antibody for WB, IHC, Indirect ELISA

Cat No. 85923-1-PBS

Clone No.250112E7

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, pig

Applications

WB, IHC, Indirect ELISA

Synonyms

Serpin I1, Peptidase inhibitor 12, PI 12, PI12, PI-12

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Product Information

85923-1-PBS targets Neuroserpin in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, pig samples.

• Tested Reactivity: human, mouse, pig
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen: Neuroserpin fusion protein Eg2819
• Full Name: serpin peptidase inhibitor, clade I (neuroserpin), member 1
• Calculated Molecular Weight: 46 kDa
• Observed Molecular Weight: 46 kDa
• GenBank Accession Number: NM_005025.4
• Gene Symbol: Neuroserpin
• Gene ID (NCBI): 5274
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purification
• UNIPROT ID: Q99574
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Neuroserpin is a member of the serpin family of serine protease inhibitors predominantly expressed in the nervous system, such as s the cerebral cortex, hippocampus and the spinal cord.Neuroserpin exerts protective effects in neurons against excitotoxicity both in vitro and in vivo. Its proteolytic inhibitory activity is shown to protect neurons against damage caused by plasmin activation. Mice overexpressing neuroserpin exhibited loss of tPA activity in the brain. Overexpression of neuroserpin in primary neurons leads to increased dendritic arborization and altered dendritic spine shape.