CoraLite®488-conjugated Noggin Monoclonal antibody
Noggin Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1
CoraLite®488 Fluorescent Dye
Cat no : CL488-69010
|Positive FC detected in||PC-3 cells|
|Sample-dependent, check data in validation data gallery|
CL488-69010 targets Noggin in FC applications and shows reactivity with Human samples.
|Host / Isotype||Mouse / IgG1|
|Immunogen||Noggin fusion protein HZ-1118|
|Gene ID (NCBI)||9241|
|Conjugate||CoraLite®488 Fluorescent Dye|
|Excitation/Emission maxima wavelengths||488 nm/515 nm|
|Purification Method||Protein G purification|
|Storage Buffer||PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.|
Noggin is an extracellular polypeptide acting as an antagonist of bone morphogenetic proteins (BMPs) regulating embryonal development. Noggin inhibits activity of BMP-2, -4, -7, -13, and -14. Noggin is present extracellularly in the matrix or retained at the cell surface via interaction with heparin sulfate proteoglycans. In early development stages, Noggin is produced by the Spemann organizer, allowing dorsal-ventral patterning of BMPs (PMID: 8752214). Subsequently, Noggin is expressed by the notochord regulating BMP-4 signaling in neurogenesis. Additionally, Noggin is present during development in the dermal papilla, connective tissue of the hair follicle, lens, retina, and periocular mesenchyme, as well as in the mesoderm lineage regulating development of the bone, cartilage, and muscles.
This antibody is used to Block/Neutralize Noggin protein.