Product Information
34123-1-PBS targets PCDH18 in IHC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag41285 Product name: Recombinant human PCDH18 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 750-900 aa of BC093815 Sequence: PSRQIHKGDITLVPTINGTLPIRSHHRSSPSSSPTLERGQMGSRQSHNSHQSLNSLVTISSNHVPENFSLELTHATPAVEQVSQLLSMLHQGQYQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEG Predict reactive species |
| Full Name | protocadherin 18 |
| Calculated Molecular Weight | 1135 aa, 126 kDa |
| GenBank Accession Number | BC093815 |
| Gene Symbol | PCDH18 |
| Gene ID (NCBI) | 54510 |
| RRID | AB_3743157 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q9HCL0 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Protocadherin 18 (PCDH18) is a member of the non-clustered protocadherin subfamily within the cadherin superfamily. Encoded by the PCDH18 gene on chromosome 4q28, it contains six to seven extracellular cadherin repeats, a transmembrane domain, and a cytoplasmic tail. PCDH18 is expressed in brain, heart, kidney, lung, and trachea. It plays critical roles in cell-cell adhesion, neuronal migration, axon guidance, and synapse formation during development. Emerging evidence links PCDH18 mutations or dysregulation to neurodevelopmental disorders, including autism spectrum disorder and intellectual disability, as well as to certain cancers (PMID: 22450339; PMID: 29075151; PMID: 28588296).
