PTCH2 Polyclonal antibody, PBS Only

• Home
• Products
• Primary Antibodies
• PTCH2 Polyclonal antibody, PBS Only (55091-1-PBS)

• 

  WB analysis of mouse liver using 55091-1-AP (same clone as 55091-1-PBS)

  Mouse liver tissue lysate was subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

• 

  WB analysis of rat liver using 55091-1-AP (same clone as 55091-1-PBS)

  Rat liver tissue lysate was subjected to SDS PAGE followed by western blot with 55091-1-AP (PTCH2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 55091-1-PBS in a different storage buffer formulation.

PTCH2 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 55091-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, Indirect ELISA

Synonyms

Patched 2, patched homolog 2 (Drosophila), Protein patched homolog 2, PTC2, UNQ560/PRO1121/PRO57079

---

Product Information

55091-1-PBS targets PTCH2 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

• Tested Reactivity: human, mouse, rat
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  Peptide

• Full Name: patched homolog 2 (Drosophila)
• Calculated Molecular Weight: 131 kDa
• Observed Molecular Weight: 131-140 kDa
• GenBank Accession Number: NM_003738
• Gene Symbol: PTCH2
• Gene ID (NCBI): 8643
• RRID: AB_10858392
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q9Y6C5
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

PTCH1 (patched homolog 1) and PTCH2 are twelve-pass transmembrane proteins that act receptors of Hedgehog signaling pathway (PMID: 8906794; 9811851). Signals of Hedgehog family proteins (SHH, IHH and DHH in humans) are transduced through Patched family receptors (PTCH1 and PTCH2) and Smoothened (SMO) to GLI family transcription factors. Hedgehog pathway plays a critical role in embryonic development and tissue homeostasis, and its dysregulation has been implicated in many human diseases including congenital disorder and cancer (PMID: 23719536; 23532857). PTCH2 may function as a tumor suppressor in the Hedgehog signaling pathway. Alterations in PTCH2 gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. This antibody is specific to PTCH2.