SEMA6B Polyclonal antibody, PBS Only

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• SEMA6B Polyclonal antibody, PBS Only (22571-1-PBS)

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  WB analysis using 22571-1-AP (same clone as 22571-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 22571-1-AP (SEMA6B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22571-1-PBS in a different storage buffer formulation.

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  IP experiment of mouse brain using 22571-1-AP (same clone as 22571-1-PBS)

  IP result of anti-SEMA6B (IP:22571-1-AP, 4ug; Detection:22571-1-AP 1:1000) with mouse brain tissue lysate 1120 ug. This data was developed using the same antibody clone with 22571-1-PBS in a different storage buffer formulation.

SEMA6B Polyclonal Antibody for WB, IP, Indirect ELISA

Cat No. 22571-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IP, Indirect ELISA

Synonyms

SEM SEMA Y, SEMA VIB, Sema Z, SEMAN, Semaphorin 6B

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Product Information

22571-1-PBS targets SEMA6B in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag16707

  Product name: Recombinant human SEMA6B protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 625-888 aa of BC142617

  Sequence: RERRELARRKDKEAILAHGAGEAVLSVSRLGERRAQGPGGRGGGGGGGAGVPPEALLAPLMQNGWAKATLLQGGPHDLDSGLLPTPEQTPLPQKRLPTPHPHPHALGPRAWDHGHPLLPASASSSLLLLAPARAPEQPPAPGEPTPDGRLYAARPGRASHGDFPLTPHASPDRRRVVSAPTGPLDPASAADGLPRPWSPPPTGSLRRPLGPHAPPAATLRRTHTFNSGEARPGDRHRGCHARPGTDLAHLLPYGGADRTAPPVP

• Full Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
• Calculated Molecular Weight: 95, 74 kDa
• Observed Molecular Weight: 70 kDa
• GenBank Accession Number: BC142617
• Gene Symbol: SEMA6B
• Gene ID (NCBI): 10501
• RRID: AB_3742073
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen Affinity purified
• UNIPROT ID: Q9H3T3
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

Semaphorins (SEMAs) play critical roles in inflammation, angiogenesis, apoptosis, fibrosis, bone remodeling, and cell invasion. SEMA6B, the sixth member of the SEMA family, has shown significant correlations with the stage of liver fibrosis in hepatitis C virus-infected patients. SEMA6B is also involved in inflammatory responses and serves as a biomarker for macrophage-specific genes. Additionally, the level of SEMA6B in circulating monocytes has predictive value for cardiovascular disease. Also, SEMA6B can be a valuable biomarker for diagnosing HBV-ACLF12 (PMID: 39267780).