SMAD6 Polyclonal antibody, PBS Only

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• SMAD6 Polyclonal antibody, PBS Only (18342-1-PBS)

• 

  WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

• 

  WB analysis using 18342-1-AP (same clone as 18342-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 18342-1-AP (SMAD6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18342-1-PBS in a different storage buffer formulation.

SMAD6 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 18342-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, Indirect ELISA

Synonyms

hSMAD6, MADH6, Mothers against DPP homolog 6, SMAD family member 6

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Product Information

18342-1-PBS targets SMAD6 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag13128

  Product name: Recombinant human SMAD6 protein

  Source: e coli.-derived, PET28a

  Tag: 6*His

  Domain: 1-496 aa of BC012986

  Sequence: MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR

• Full Name: SMAD family member 6
• Calculated Molecular Weight: 53 kDa
• Observed Molecular Weight: 52 kDa
• GenBank Accession Number: BC012986
• Gene Symbol: SMAD6
• Gene ID (NCBI): 4091
• RRID: AB_3741951
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O43541
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

SMAD6 is an intracellular signal transduction protein that belongs to the SMAD protein family. It acts as a negative regulator in the transforming growth factor-beta (TGF-β) signaling pathway, binding to TGF-β receptors and inhibiting the phosphorylation of SMAD2/SMAD3, thereby blocking the transmission of TGF-β signals. Additionally, SMAD6 is involved in the regulation of the bone morphogenetic protein (BMP) signaling pathway, affecting cell proliferation, differentiation, and apoptosis. During development, SMAD6 is crucial for the formation of bones and cartilage. Its abnormal expression is associated with various diseases, including skeletal developmental abnormalities and certain types of cancer.