alpha-synuclein Antibody 9 Publications

Rabbit Polyclonal| Catalog number: 10842-1-AP

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Freight/Packing

Con: 76 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
mouse brain tissue, human brain tissue, SH-SY5Y cells

Positive IHC detected in:
mouse brain tissue, human kidney tissue, human lung tissue, human placenta tissue, human skin tissue, human testis tissue

Positive IF detected in:
SH-SY5Y cells, mouse brain tissue

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
synuclein, alpha (non A4 component of amyloid precursor)

Calculated molecular weight:
14 kDa

Observed molecular weight:
15-19 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
SNCA

Synonyms
Alpha synuclein, NACP, PARK1, PARK4, SNCA
Background

alpha-synuclein (α-syn) is a 14-19 kDa phosphoprotein that is primarily localize to the presynaptic terminals of mature neurons, where it is involved in synaptic function and plasticity. Α-syn has drawn intense interest ever since the late 1990s, when the first α-synuclein missense mutation was identified as a cause of familial Parkinson’s disease (PD). Aggregated and hyper-phosphorylated forms of α-syn protein are the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV). This antibody can recognize all the isoforms of α-syn.


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