Product Information
16739-1-PBS targets TASP1 in WB, IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag9918 Product name: Recombinant human TASP1 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-420 aa of BC025266 Sequence: MTMEKGMSSGEGLPSRSSQVSAGKITAKELETKQSYKEKRGGFVLVHAGAGYHSESKAKEYKHVCKRACQKAIEKLQAGALATDAVTAALVELEDSPFTNAGMGSNLNLLGEIECDASIMDGKSLNFGAVGALSGIKNPVSVANRLLCEGQKGKLSAGRIPPCFLVGEGAYRWAVDHGIPSCPPNIMTTRFSLAAFKRNKRKLELAERVDTDFMQLKKRRQSSEKENDSGTLDTVGAVVVDHEGNVAAAVSSGGLALKHPGRVGQAALYGCGCWAENTGAHNPYSTAVSTSGCGEHLVRTILARECSHALQAEDAHQALLETMQNKFISSPFLASEDGVLGGVIVLRSCRCSAEPDSSQNKQTLLVEFLWSHTTESMCVGYMSAQDGKAKTHISRLPPGAVAGQSVAIEGGVCRLESPVN Predict reactive species |
| Full Name | taspase, threonine aspartase, 1 |
| Calculated Molecular Weight | 420 aa, 44 kDa |
| Observed Molecular Weight | 50 kDa |
| GenBank Accession Number | BC025266 |
| Gene Symbol | TASP1 |
| Gene ID (NCBI) | 55617 |
| RRID | AB_2201218 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9H6P5 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
Threonine aspartase 1 (TASP1), a particularly conserved protease that cleaves mixed lineage leukemia 1 (MLL), regulates the expression of homeotic genes and is involved in the occurrence of cancer. TASP1 drives cell cycle progression and coordinates cell proliferation and apoptosis (PMID: 33767369). Aberrant expression of TASP1 has been found in numerous liquid and solid malignancies, including leukaemia, breast cancer, lung cancer, head and neck cancer, brain cancer, colon cancer, glioblastoma and melanoma. TASP1 plays a key role in cancer cell proliferation and apoptosis and can inhibit tumor growth after knockout (PMID: 32071545, 34012990).





























