Product Information
31975-1-PBS targets TEF in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag37096 Product name: Recombinant human TEF protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 11-185 aa of BC039258 Sequence: PVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARLDKEKGKEKLEEDEAAAASTMAVSASLMPPIWDKTIPYDGESFHLEYMDLDEFLLENGIPASPTHLAHNLLLPVAELEGKESASSSTASPPSSSTAIFQPSETVSSTESSLEKERETPSPIDPNCVEVDVNFNP Predict reactive species |
| Full Name | thyrotrophic embryonic factor |
| Observed Molecular Weight | 28 kDa |
| GenBank Accession Number | BC039258 |
| Gene Symbol | TEF |
| Gene ID (NCBI) | 7008 |
| RRID | AB_3742504 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity Purification |
| UNIPROT ID | Q10587 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TEF (Thyrotroph Embryonic Factor) is a member of the PAR bZIP transcription factor family. Initially identified as being specifically expressed in pituitary thyrotroph cells during embryonic development, it regulates the transcription of the thyroid-stimulating hormone (TSH-β) gene. TEF activates target genes by binding to specific DNA sequences and is involved in cell cycle regulation, proliferation, and differentiation. Recent studies have revealed that TEF is significantly downregulated in various cancers, including bladder cancer, where it functions as a tumor suppressor by inhibiting tumor cell proliferation and metastasis through the AKT/FOXOs and Hippo signaling pathways, making it a potential tumor biomarker. In addition, as a regulator of circadian rhythms, polymorphisms in the TEF gene are associated with neuropsychiatric disorders such as Parkinson's disease, depression, and sleep disorders.
