TGF-beta 1 Antibody 40 Publications

Rabbit Polyclonal| Catalog number: 18978-1-AP

  • Print page
  • Download PDF

-_-

Freight/Packing

Con: 33 μg/150 μl

Choose size:

Please visit your regions distributor:

Tested Applications

Applications:
ELISA, IF, IHC, WB
Application not tested? Please see our Guarantee




Species specificity:
human, mouse, rat, human; dog; miniping;rat; sheep; buffloa; pig

Recommended dilution:

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
transforming growth factor, beta 1

Calculated molecular weight:
44 kDa

Observed molecular weight:

GenBank accession number:

Gene ID (NCBI):

Gene symbol
TGFB1

Synonyms
CED, DPD1, LAP, TGF beta 1, TGFB, TGFB1, TGFbeta, TGF-beta1, TGF-β1
Background

TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1). Full length, inactive 44 kD TGFB1 is cleaved into mature TGFB1 (13 kD). TGFB1 also homodimerizes and heterodimerizes with TGFB2, so there is potential for multiple different band sizes in WB (12, 25, 45 to 65 kDa).


Back
to top