THBD Monoclonal antibody

THBD Monoclonal Antibody for WB,ELISA

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB,ELISA

Conjugate

Unconjugated

CloneNo.

5A4C5

Cat no : 67831-1-Ig

Synonyms

CD141, Fetomodulin, THBD, THRM, thrombomodulin, TM



Tested Applications

Positive WB detected inhuman placenta tissue

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:4000
Sample-dependent, check data in validation data gallery

Product Information

67831-1-Ig targets THBD in WB,ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen THBD fusion protein Ag5723
Full Name thrombomodulin
Calculated molecular weight 60 kDa
Observed molecular weight105 kDa
GenBank accession numberBC035602
Gene symbol THBD
Gene ID (NCBI) 7056
Conjugate Unconjugated
Form Liquid
Purification Method Protein A purification
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage ConditionsStore at -20°C. Aliquoting is unnecessary for -20oC storage.

Background Information

Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310).

Protocols

Product Specific Protocols
WB protocol for THBD antibody 67831-1-IgDownload protocol
IHC protocol for THBD antibody 67831-1-IgDownload protocol
Standard Protocols
Click here to view our Standard Protocols