Product Information
11333-1-PBS targets TIFA in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag1876 Product name: Recombinant human TIFA protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-184 aa of BC014259 Sequence: MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTFQDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFGEYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMDENES Predict reactive species |
| Full Name | TRAF-interacting protein with forkhead-associated domain |
| Calculated Molecular Weight | 21 kDa |
| Observed Molecular Weight | 21 kDa |
| GenBank Accession Number | BC014259 |
| Gene Symbol | TIFA |
| Gene ID (NCBI) | 92610 |
| RRID | AB_3669126 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q96CG3 |
| Storage Buffer | PBS only, pH 7.3. |
| Storage Conditions | Store at -80°C. |
Background Information
TIFA (TRAF-interacting protein with FHA domain-containing protein A ), also called T2BP, can interact with TRAF6 and plays an important role in innate immunity (PMID: 32910997; 35635239). Oligomerization of TIFA, which induces oligomerization and polyubiquitinylation of TRAF6, in turn activates TAK and IKK, finally mediates NF‐κB activation in the Toll‐like receptor 4/interleukin‐1 signaling pathway (PMID: 15492226; 22566686). It has been reported that TIFA also plays various roles in different cancer types (PMID: 26501855; 29263897).
