ZNF746 Polyclonal antibody, PBS Only

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• ZNF746 Polyclonal antibody, PBS Only (24543-1-PBS)

• 

  WB analysis using 24543-1-AP (same clone as 24543-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

• 

  WB analysis of HEK-293T using 24543-1-AP (same clone as 24543-1-PBS)

  HEK-293T cells were subjected to SDS PAGE followed by western blot with 24543-1-AP (ZNF746 antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24543-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

ZNF746 Polyclonal Antibody for WB, Indirect ELISA

Cat No. 24543-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, Indirect ELISA

Synonyms

Zinc finger protein 746, Parkin-interacting substrate, PARIS, FLJ31413

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Product Information

24543-1-PBS targets ZNF746 in WB, Indirect ELISA applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag21566

  Product name: Recombinant human ZNF746 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 186-531 aa of BC068505

  Sequence: MQIKQEGELQLQEQQALGVEAWAAGQPDIGEEPWGLSQLDSGAGDISTDATSGVHSNFSTTIPPTSWQTDLPPHHPSSACSDGTLKLNTAASTEDVKIVIKTEVQEEEVVATPVHPTDLEAHGTLFGPGQATRFFPSPAQEGAWESQGSSFPSQDPVLGLREPARPERDMGELSPAVAQEETPPGDWLFGGVRWGWNFRCKPPVGLNPRTGPEGLPYSSPDNGEAILDPSQAPRPFNEPCKYPGRTKGFGHKPGLKKHPAAPPGGRPFTCATCGKSFQLQVSLSAHQRSCGAPDGSGPGTGGGGSGSGGGGGGSGGGSARDGSALRCGECGRCFTRPAHLIRHRML

• Full Name: zinc finger protein 746
• Calculated Molecular Weight: 644 aa, 69 kDa
• Observed Molecular Weight: 85-95 kDa
• GenBank Accession Number: BC068505
• Gene Symbol: ZNF746
• Gene ID (NCBI): 155061
• RRID: AB_2879598
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: Q6NUN9
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ZNF746, also named as PARIS, which belongs to the krueppel C2H2-type zinc-finger protein family. ZNF746 mainly localizes to the cytoplasm and probably translocates to the nucleus to repress selected genes. ZNF746 as a transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death. ZNF746 may act as a downstream effector of PRKN and contribute to neurodegeneration in Parkinson disease cases caused by defects in PRKN (PMID: 28122242). The calculated molecular weight of ZNF746 is 69 kDa, but Phosphorylation of ZNF746 is about 80-85 kDa (PMID: 28122242).