ChromoTek anti-OSM recombinant VHH, biotinylated

Validation Data Gallery

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  BLI analysis of the capture of varying concentrations of HumanKine OSM (HZ-1030) by biotinylated anti-OSM VHH (osm-b). Please note the higher apparent affinity owing to avidity effects (dimerization of the cytokine).

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  ELISA analysis of the capture of varying concentrations of HumanKine OSM (HZ-1030) by biotinylated anti-OSM (osm-b). Detection via rabbit polyclonal PTG 27792-1-AP.

osm-b is a recombinant mono-biotinylated anti OSM Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.

Cat No. osm-b

Host/Type

Alpaca VHH

Reactivity

Human

Applications

BLI, SPR, ELISA

Conjugate

Biotin

Synonyms

OSM-VHH, OSM single domain antibody (sdAb), OSM, Oncostatin-M

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Product Information

osm-b is a recombinant mono-biotinylated anti OSM Nanobody (VHH), suitable for ELISA, SPR, and BLI applications.

• Applications: BLI, SPR, ELISA
• Reactivity: Human
• Conjugate: Biotin
• Type: Nanobody
• Class: Recombinant
• Host: Alpaca
• Affinity: 120 nM
• Molecular Weight: 13.9 kDa
• Form: Liquid
• RRID: AB_3665413
• Storage Buffer: 10 mM HEPES pH 7.0, 500 mM NaCl, 5 mM EDTA, 0.09% sodium azide
• Storage Condition: Store at -20°C
• Shipping: ambient
• Background: Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).

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