ChromoTek anti-OSM recombinant VHH, for 1x Cys conjugation

Validation Data Gallery

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  BLI analysis of the interaction between varying concentrations of anti-OSM VHH and immobilised, biotinylated HumanKine OSM (HZ-1030). Fit indicates fitting of data to a 1:1 binding model.

osmCys1 is an unconjugated recombinant anti OSM Nanobody (VHH). Suitable for for cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

Cat No. osmCys1

Host/Type

Alpaca VHH

Reactivity

Human

Applications

Conjugation

Conjugate

Unconjugated

Synonyms

OSM-VHH, OSM single domain antibody (sdAb), OSM, Oncostatin-M

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Product Information

osmCys1 is an unconjugated recombinant anti OSM Nanobody (VHH). Suitable for for cysteine conjugation with thiol-reactive reagents, e.g. maleimides. Note: unconjugated VHHs are not suited for usage without prior labeling, since they contain reactive Cysteines. Shipment and storage buffers contain TCEP to keep Cysteines reduced.

• Applications: Conjugation
• Reactivity: Human
• Conjugate: Unconjugated
• Type: Nanobody
• Class: Recombinant
• Host: Alpaca
• Affinity: 120 nM
• Molecular Weight: 13.9 kDa
• Form: Liquid
• RRID: AB_3665414
• Storage Buffer: 10 mM HEPES pH 7.0, 500 mM NaCl, 0.09% sodium azide
• Storage Condition: Store at -20°C
• Shipping: dry ice
• Background: Oncostatin M (OSM) is a member of a cytokine family that includes a leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM is a growth regulator which inhibits the proliferation of some tumor cell lines. It can stimulate proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF, and GM-CSF from endothelial cells. OSM is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (PMID: 9133674; 29526757; 29363180; 21887386).

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