beta-Catenin Antibody 73 Publications

Rabbit Polyclonal| Catalog number: 51067-2-AP

Featured Product KD/KO validated

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Freight/Packing

Con: 35 μg/150 μl

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Species specificity:
human, mouse, rat, pig, goat, hamster

Positive WB detected in:
HEK-293 cells,NIH/3T3 cells, HeLa cells , MCF-7 cells, mouse liver tissue, human placenta tissue, mouse lung tissue, A431 cells, rat liver tissue, SH-SY5Y cells

Positive IP detected in:
mouse liver tissue

Positive IHC detected in:
human breast cancer tissue,human liver cancer tissue, human colon cancer tissue, human stomach cancer tissue

Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:100-1:400
IF : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Immunogen:
Peptide

Full name:
catenin (cadherin-associated protein), beta 1, 88kDa

Calculated molecular weight:
781aa,86 kDa

Observed molecular weight:
92 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CTNNB1

Synonyms
b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, DKFZp686D02253, FLJ25606, FLJ37923, PRO2286, β catenin, β-catenin
Background

β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)


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