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CoraLite®555-conjugated Beta Catenin Polyclonal antibody
Beta Catenin Polyclonal Antibody for IF
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat, pig
Applications
IF
Conjugate
CoraLite®555 Fluorescent Dye
Cat no : CL555-51067
Synonyms
Validation Data Gallery
Tested Applications
Positive IF detected in | MCF-7 cells, human liver cancer tissue |
Recommended dilution
Application | Dilution |
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Immunofluorescence (IF) | IF : 1:50-1:500 |
Sample-dependent, check data in validation data gallery |
Product Information
CL555-51067 targets Beta Catenin in IF applications and shows reactivity with human, mouse, rat, pig samples.
Tested Reactivity | human, mouse, rat, pig |
Host / Isotype | Rabbit / IgG |
Class | Polyclonal |
Type | Antibody |
Immunogen | Peptide |
Full Name | catenin (cadherin-associated protein), beta 1, 88kDa |
Calculated molecular weight | 781 aa, 86 kDa |
Observed molecular weight | 92 kDa |
GenBank accession number | BC058926 |
Gene symbol | CTNNB1 |
Gene ID (NCBI) | 1499 |
Conjugate | CoraLite®555 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 557 nm / 570nm |
Form | Liquid |
Purification Method | Antigen affinity purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
β-Catenin, also known as CTNNB1, is an evolutionarily conserved, multifunctional intracellular protein. β-Catenin is a 92-kDa protein, originally identified in cell adherens junctions (AJs) where it functions to bridge the cytoplasmic domain of cadherins to a-catenin and the actin cytoskeleton. Besides its essential role in the AJs, β-catenin is also a key downstream component of the canonical Wnt pathway that plays diverse and critical roles in embryonic development and adult tissue homeostasis. The Wnt/β-catenin pathway is also involved in the activation of other intracellular messengers such as calcium fluxes, JNK, and SRC kinases. Deregulation of β-catenin activity is associated with multiple diseases including cancers. (PMID: 22617422; 18334222)
Protocols
Product Specific Protocols | |
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IF protocol for CL555 Beta Catenin antibody CL555-51067 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |