CD80 Monoklonaler Antikörper
CD80 Monoklonal Antikörper für FC
Wirt / Isotyp
Armenian Hamster / IgG
Getestete Reaktivität
Maus
Anwendung
IF, FC
Konjugation
FITC Plus Fluorescent Dye
CloneNo.
16-10A1
Kat-Nr. : FITC-65076
Synonyme
Geprüfte Anwendungen
| Erfolgreiche Detektion in FC | Balb/c peritoneale Makrophagen der Maus |
Empfohlene Verdünnung
| Anwendung | Verdünnung |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, check data in validation data gallery | |
Veröffentlichte Anwendungen
| IF | See 2 publications below |
| FC | See 14 publications below |
Produktinformation
FITC-65076 bindet in IF, FC CD80 und zeigt Reaktivität mit Maus
| Getestete Reaktivität | Maus |
| In Publikationen genannte Reaktivität | Maus |
| Wirt / Isotyp | Armenian Hamster / IgG |
| Klonalität | Monoklonal |
| Typ | Antikörper |
| Immunogen | CHO-Zelllinie transfiziert mit Maus-B7 (CD80) |
| Vollständiger Name | CD80 antigen |
| GenBank-Zugangsnummer | BC131959 |
| Gene symbol | CD80 |
| Gene ID (NCBI) | 12519 |
| Konjugation | FITC Plus Fluorescent Dye |
| Excitation/Emission maxima wavelengths | 495 nm / 524 nm |
| Form | Liquid |
| Reinigungsmethode | Affinitätsreinigung |
| Lagerungspuffer | PBS with 0.09% sodium azide |
| Lagerungsbedingungen | Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment. |
Hintergrundinformationen
CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)
Protokolle
| PRODUKTSPEZIFISCHE PROTOKOLLE | |
|---|---|
| FC protocol for FITC Plus CD80 antibody FITC-65076 | Download protocol |
| STANDARD-PROTOKOLLE | |
|---|---|
| Klicken Sie hier, um unsere Standardprotokolle anzuzeigen |
Publikationen
| Species | Application | Title |
|---|---|---|
ACS Appl Mater Interfaces Combined Chemo-Immuno-Photothermal Therapy for Effective Cancer Treatment via an All-in-One and One-for-All Nanoplatform | ||
ACS Appl Mater Interfaces Intelligent Nanoplatform Integrating Macrophage and Cancer Cell Membrane for Synergistic Chemodynamic/Immunotherapy/Photothermal Therapy of Breast Cancer | ||
Cell Rep Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells | ||
ACS Appl Mater Interfaces Dual-Regulated Biomimetic Nanocomposites For Promoted Tumor Photodynamic Immunotherapy | ||
Neurobiol Dis Inhibitory effects of xanthine oxidase inhibitor, topiroxostat, on development of neuropathy in db/db mice. | ||
Nat Commun CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis |
