COXIV Monoklonaler Antikörper

COXIV Monoklonal Antikörper für ELISA

Wirt / Isotyp

Maus / IgG1

Getestete Reaktivität

human und mehr (2)

Anwendung

WB, IF, ELISA

Konjugation

Unkonjugiert

Publikationen

7

CloneNo.

3C7D2

Kat-Nr. : 60251-1-Ig

Synonyme

Cell and organelle markers, COX IV 1, COX4, COX4I1, COXIV, Cytochrome c oxidase polypeptide IV, Cytochrome c oxidase subunit 4 isoform 1 mitochondrial, Mitochondria Marker, Mitochondrial Marker, Mitochondrion Marker

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Galerie der Validierungsdaten

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  IHC staining of human prostate cancer using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human prostate cancer using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human prostate cancer using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human prostate cancer using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human pancreas using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human pancreas using 60251-1-Ig(COXIV antibody) at dilution of 1:100 (under 10x lens).

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  IHC staining of human pancreas using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human pancreas using 60251-1-Ig(COXIV antibody) at dilution of 1:100 (under 40x lens).

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  IHC staining of human pancreas using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human pancreas using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human pancreas using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human pancreas using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 40x lens).

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  IHC staining of human heart using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human heart using 60251-1-Ig(COXIV antibody) at dilution of 1:100 (under 10x lens).

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  IHC staining of human heart using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human heart using 60251-1-Ig(COXIV antibody) at dilution of 1:100 (under 40x lens).

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  IHC staining of human heart using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human heart using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 10x lens).

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  IHC staining of human heart using 60251-1-Ig

  Immunohistochemical analysis of paraffin-embedded human heart using 60251-1-Ig(COXIV antibody) at dilution of 1:200 (under 40x lens).

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  IF Staining of HeLa using 60251-1-Ig

  Immunofluorescent analysis of HeLa cells using 60251-1-Ig (COXIV antibody) at dilution of 1:25 and Rhodamine-Goat anti-Mouse IgG.

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Geprüfte Anwendungen

Empfohlene Verdünnung

Anwendung	Verdünnung
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, check data in validation data gallery

Veröffentlichte Anwendungen

• WB: See 4 publications below
• IF: See 5 publications below

Produktinformation

60251-1-Ig bindet in WB, IF, ELISA COXIV und zeigt Reaktivität mit human

• Getestete Reaktivität: human
• In Publikationen genannte Reaktivität: human, Maus, Ratte
• Wirt / Isotyp: Maus / IgG1
• Klonalität: Monoklonal
• Typ: Antikörper
• Immunogen: COXIV fusion protein Ag20551
• Vollständiger Name: cytochrome c oxidase subunit IV isoform 1
• Berechnetes Molekulargewicht: 19.6 kDa
• Beobachtetes Molekulargewicht: 17-18 kDa
• GenBank-Zugangsnummer: BC021236
• Gene symbol: COX4I1
• Gene ID (NCBI): 1327
• Konjugation: Unkonjugiert
• Form: Liquid
• Reinigungsmethode: Protein-G-Reinigung
• Lagerungspuffer: PBS mit 0.02% Natriumazid und 50% Glycerin pH 7.3.
• Lagerungsbedingungen: Bei -20°C lagern. Nach dem Versand ein Jahr lang stabil Aliquotieren ist bei -20^oC Lagerung nicht notwendig. 20ul Größen enthalten 0,1% BSA.

Hintergrundinformationen

COX4I1, also named as COX4 and COXIV-1, belongs to the cytochrome c oxidase IV family. It is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. COX4I1 is a marker for mitochondria. It has two isoforms (isoform 1 and 2). Isoform 1(COX4I1) is ubiquitously expressed and isoform 2 is highly expressed in lung tissues. COX4I1 is commonly used as a loading control. This antibody is specific to COX4I1 and do not cross reacts with COX4I2.

Publikationen

Species	Application	Title
human	WB	Autophagy; The nucleoprotein of influenza A virus inhibits the innate immune response by inducing mitophagy; Authors - Bo Zhang
human	IF	Hypertension; Upregulation of Piezo1 (Piezo Type Mechanosensitive Ion Channel Component 1) Enhances the Intracellular Free Calcium in Pulmonary Arterial Smooth Muscle Cells From Idiopathic Pulmonary Arterial Hypertension Patients.; Authors - Jing Liao
mouse	IF	Mol Metab; Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis and lean mass.; Authors - Rebecca J Wilson
mouse	IF	Mol Cell Biol; Protein Kinase A/CREB Signaling Prevents Adriamycin-Induced Podocyte Apoptosis via Upregulation of Mitochondrial Respiratory Chain Complexes.; Authors - Kewei Xie
rat	WB,IF	Eur J Histochem; Transcription factor nuclear factor erythroid 2 p45-related factor 2 (NRF2) ameliorates sepsis-associated acute kidney injury by maintaining mitochondrial homeostasis and improving the mitochondrial function.; Authors - Zhijiang Chen
rat	WB	Cells; Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats.; Authors - Qi He