ARHGEF11 Polyclonal antibody, PBS Only

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• ARHGEF11 Polyclonal antibody, PBS Only (30508-1-PBS)

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  WB analysis using 30508-1-AP (same clone as 30508-1-PBS)

  Various lysates were subjected to SDS PAGE followed by western blot with 30508-1-AP (ARHGEF11 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

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  WB analysis of HEK-293T using 30508-1-AP (same clone as 30508-1-PBS)

  WB result of ARHGEF11 antibody (30508-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-ARHGEF11 transfected HEK-293T cells. This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

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  IHC staining of mouse colon using 30508-1-AP (same clone as 30508-1-PBS)

  Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 30508-1-AP (ARHGEF11 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 30508-1-PBS in a different storage buffer formulation.

• Featured Product
• KD/KO Validated

ARHGEF11 Polyclonal Antibody for WB, IHC, Indirect ELISA

Cat No. 30508-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, Indirect ELISA

Synonyms

GTRAP48, KIAA0380, PDZ RHOGEF

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Product Information

30508-1-PBS targets ARHGEF11 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

• Tested Reactivity: human, mouse
• Host / Isotype: Rabbit / IgG
• Class: Polyclonal
• Type: Antibody
• Immunogen:

  CatNo: Ag33104

  Product name: Recombinant human ARHGEF11 protein

  Source: e coli.-derived, PGEX-4T

  Tag: GST

  Domain: 1223-1522 aa of

  Sequence: ETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQAPPGGEGDNTQLAGLEGERPEQEDMGLCSLEHLPPRTRNSGIWESPELDRNLAEDASSTEAAGGYKVVRKAEVAGSKVVPALPESGQSEPGPPEVEGGTKATGNCFYVSMPSGPPDSSTDHSEAPMSPPQPDSLPAGQTEPQPQLQGGNDDPRRPSRSPPSLALRDVGMIFHTIEQLTLKLNRLKDMELAHRELLKSLGGESSGGTTPVGSFHTEAARWTDGSLSPPAKEPLASDSRNSHELGPCPEDGSDAPLEDSTADAAASPGP

• Full Name: Rho guanine nucleotide exchange factor (GEF) 11
• Calculated Molecular Weight: 168 kDa
• Observed Molecular Weight: 200-220 kDa
• Gene Symbol: ARHGEF11
• Gene ID (NCBI): 9826
• RRID: AB_3086341
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Antigen affinity purification
• UNIPROT ID: O15085
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

ARHGEF11 (Rho guanine nucleotide exchange factor 11) is a specific guanine nucleotide exchange factor (GEF) for RhoA, which is a critical regulator of actin cytoskeleton dynamics and organization of dendritic spines and inhibitor of spine maintenance (PMID: 28036092). ARHGEF11 has been proven to promote tumor metastasis in glioblastoma and ovarian carcinoma (PMID: 33122451).