GRP94 Antibody 0 Publications

Mouse Monoclonal| Catalog number: 60012-1-Ig |CloneNo.: 1H10B7

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Freight/Packing

Con: 150 μg/150 μl

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Species specificity:
human, mouse, rat

Positive WB detected in:
Human heart, human heart tissue

Positive IHC detected in:
human lung cancer tissue, human breast cancer tissue, human lung cancer tissue

Positive IF detected in:
Hela cells, HepG2 cells, MCF-7 cells

Positive FC detected in:
HeLa cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgM

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
heat shock protein 90kDa beta (Grp94), member 1

Calculated molecular weight:
96 kDa

Observed molecular weight:
95 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
HSP90B1

Synonyms
ECGP, GP96, GRP 94, GRP94, HSP90B1, TRA1, Tumor rejection antigen 1
Background

HSP90 proteins are highly conserved molecular chaperones, which normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. HSP90B1 (GP96 or GRP94) is an endoplasmic reticulum paralogue of the cytosolic HSP90. As a major ER chaperone to mediate the UPR and a master chaperone for Toll-like receptors (TLRs), HSP90b1 chaperones peptides to MHC class I molecules of dendritic cells and other antigen-presenting cells, as well as facilitating the assembly of immunoglobulin. The protein is also involved in many other bio-processes. This antibody was generated against the N-terminal region of full-length HSP90b1.


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