CoraLite® Plus 647-conjugated IBA1 Monoclonal antibody
IBA1 Monoclonal Antibody for FC (Intra)
Host / Isotype
Mouse / IgG2a
CoraLite® Plus 647 Fluorescent Dye
Cat no : CL647-66827
|Positive FC detected in
|Flow Cytometry (FC)
|FC : 0.20 ug per 10^6 cells in a 100 µl suspension
|It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
|Sample-dependent, check data in validation data gallery
CL647-66827 targets IBA1 in FC (Intra) applications and shows reactivity with human samples.
|Host / Isotype
|Mouse / IgG2a
|IBA1 fusion protein Ag28236
|allograft inflammatory factor 1
|Calculated molecular weight
|GenBank accession number
|Gene ID (NCBI)
|CoraLite® Plus 647 Fluorescent Dye
|Excitation/Emission maxima wavelengths
|654 nm / 674 nm
|Protein G purification
|PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
|Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.
AIF1, also named as G1, IBA1 or daintain/AIF-1, is a 143 amino acid cytoplasmic, inflammation response scaffold protein. It is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.