Anti-Human IL-17RA Rabbit Recombinant Antibody, PBS Only

• 

  FC experiment of human peripheral blood leukocytes using 98271-1-RR (same clone as 98271-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-17RA/CD217 Rabbit Recombinant Antibody (98271-1-RR, Clone: 241891G7) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were co-stained with CoraLite® Plus 647 Anti-Human CD16 (3G8). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98271-1-PBS in a different storage buffer formulation.

• 

  FC experiment of human peripheral blood leukocytes using 98271-1-RR (same clone as 98271-1-PBS)

  1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human IL-17RA/CD217 Rabbit Recombinant Antibody (98271-1-RR, Clone: 241891G7) (red) or Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed. This data was developed using the same antibody clone with 98271-1-PBS in a different storage buffer formulation.

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  Affinity and Kinetic Characterization of 98271-1-RR

  Biolayer interferometry (BLl) kinetic assays of 98271-1-RR against Human IL-17RA/CD217 were performed. The affinity constant is 0.115 nM.

IL-17RA Uni-rAb^® Recombinant Antibody for FC

Cat No. 98271-1-PBS

Clone No.241891G7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

FC

Synonyms

CD217, IL17RA, 241891G7, CANDF5, CDw217

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Product Information

98271-1-PBS targets IL-17RA in FC applications and shows reactivity with human samples.

• Tested Reactivity: human
• Host / Isotype: Rabbit / IgG
• Class: Recombinant
• Type: Antibody
• Immunogen:

  CatNo: Eg2317

  Product name: Recombinant Human IL-17RA protein (rFc Tag)

  Source: mammalian cells-derived, pHZ-KIsec-C-rFc

  Tag: C-rFc

  Domain: 33-320 aa of BC011624

  Sequence: LRLLDHRALVCSQPGLNCTVKNSTCLDDSWIHPRNLTPSSPKDLQIQLHFAHTQQGDLFPVAHIEWTLQTDASILYLEGAELSVLQLNTNERLCVRFEFLSKLRHHHRRWRFTFSHFVVDPDQEYEVTVHHLPKPIPDGDPNHQSKNFLVPDCEHARMKVTTPCMSSGSLWDPNITVETLEAHQLRVSFTLWNESTHYQILLTSFPHMENHSCFEHMHHIPAPRPEEFHQRSNVTLTLRNLKGCCRHQVQIQPFFSSCLNDCLRHSATVSCPEMPDTPEPIPDYMPLW

• Full Name: interleukin 17 receptor A
• Calculated Molecular Weight: 866 aa, 96 kDa
• GenBank Accession Number: BC011624
• Gene Symbol: IL17RA
• Gene ID (NCBI): 23765
• Conjugate: Unconjugated
• Form: Liquid
• Purification Method: Protein A purfication
• UNIPROT ID: Q96F46
• Storage Buffer: PBS only, pH 7.3.
• Storage Conditions: Store at -80°C.

Background Information

IL-17 is a proinflammatory cytokine. IL-17 can signal as homodimers or heterodimers through a heterodimeric receptor formed by IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC) subunits. IL-17RA is ubiquitously expressed in both the epithelial and hematopoietic cell compartments. IL-17/IL-17RA signaling plays an important physiological role in regulating the mucosal host defense against invading microorganisms, but it can also play pathogenic roles in several inflammatory or autoimmune conditions; furthermore, it has been described as pro-tumorigenic in several cancer types.