CoraLite®594-conjugated NeuN Polyclonal antibody
NeuN Polyclonal Antibody for FC (Intra), IF
Host / Isotype
Rabbit / IgG
human, mouse, rat, pig
IF, FC (Intra)
CoraLite®594 Fluorescent Dye
Cat no : CL594-26975
|Positive IF detected in||mouse brain tissue|
|Positive FC detected in||U-87 MG cells|
|Immunofluorescence (IF)||IF : 1:50-1:500|
|Sample-dependent, check data in validation data gallery|
The immunogen of CL594-26975 is NeuN Fusion Protein expressed in E. coli.
|Tested Reactivity||human, mouse, rat, pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||NeuN fusion protein Ag25689|
|Full Name||hexaribonucleotide binding protein 3|
|Observed molecular weight||46-52 kDa|
|GenBank accession number||NM_001082575|
|Gene ID (NCBI)||146713|
|Conjugate||CoraLite®594 Fluorescent Dye|
|Excitation/Emission maxima wavelengths||593 nm / 614 nm|
|Purification Method||Antigen affinity purification|
|Storage Buffer||PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.|
|Storage Conditions||Store at -20°C. Avoid exposure to light. Aliquoting is unnecessary for -20oC storage.|
NeuN, also known as FOX3 or RBFOX3, belongs to a family of tissue-specific splicing regulators and is involved in neural circuitry balance, as well as neurogenesis and synaptogenesis (PMID: 26619789).
NeuN is exclusively present in post-mitotic neurons and is absent from neural progenitors, oligodendrocytes, astrocytes, and glia (PMID: 1483388).
Involvement in disease
· NeuN cytoplasmic localization is increased in the neurons of patients with HIV-associated neurocognitive disorders (PMID: 24215932).
There are 4 isoforms of NeuN, migrating in the 45-50 kDa range (PMID: 21747913).
Currently not known.
NeuN predominantly localizes to the nucleus but can also be present in the cytoplasm. Isoforms of NeuN differ in their cytoplasmic/nucleus localization (PMID: 21747913).