KD/KO Validated
KD/KO Validated
| Antibody | Catalog number | Type | Applications |
| STAT3 | 10253-2-AP | Rabbit Poly | ELISA, ChIP, FC, IF, IHC, IP, WB |
STAT3, one of the latent cytoplasmic transcription factors, mediates the expression of a broad gene variety in response to cell stimuli, and thus plays a key role in cell growth and apoptosis. While working with Proteintech STAT3 antibodies, Yan and colleagues suggested that cancer-associated fibroblasts (CAFs) may activate the anti-apoptotic STAT3 signaling, and decrease Cisplatin-induced apoptosis, thereby promoting chemoresistance in ovarian cancer.¹ Furthermore, another research group using STAT3 antibodies suggested Arctigenin (Atn) as a promising drug candidate for designing new and effective STAT3 inhibitors.²
Immunofluorescent analysis of HeLa cells using STAT3 antibody (10253-2-AP) at a dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.
Related Products
| Antibody | Catalog number | Type | Applications |
| STAT1 - KD/KO Validated | 10144-2-AP | Rabbit Poly | ELISA, FC, IF, IHC, IP, WB |
| STAT2 | 16674-1-AP | Rabbit Poly | ELISA, IHC, IP, WB |
| STAT3 | 51076-2-AP | Rabbit Poly | ELISA, IHC, IP, WB |
| STAT3 - KD/KO Validated | 60199-1-Ig | Mouse Mono | ELISA, IF, IHC, IP, WB |
| STAT4 | 51070-2-AP | Rabbit Poly | ELISA, IF, IHC, WB |
| STAT5A | 13179-1-AP | Rabbit Poly | ELISA, FC, IHC, IP, WB |
| STAT5A | 66459-1-Ig | Mouse Mono | ELISA, WB |
| STAT5B | 12071-1-AP | Rabbit Poly | ELISA, IF, IHC, IP, WB |
| STAT6 | 51073-1-AP | Rabbit Poly | ELISA, IF, IHC, WB |
References
1. Cancer-associated fibroblasts attenuate Cisplatininduced apoptosis in ovarian cancer cells by promoting STAT3 signaling, (PMID: 26826383).
2. Arctigenin inhibits STAT3 and exhibits anticancer potential in human triple-negative breast cancer therapy, (PMID: 27861147).