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NSPs (Non-Structural Proteins)

Understanding the role of non-structural proteins (NSPs) and their implication in long-term severe repercussions of SARS-CoV-2 infection

Understanding the role of non-structural proteins (NSPs) and their implication in long-term severe repercussions of SARS-CoV-2 infection


Since the onset of the COVID-19 pandemic, research into coronaviruses; specifically SARS-CoV-2, has increased exponentially. Study of the viral spike protein, and targets such as ACE2 and TRPMSS2 have been some of the most popular research topics. Understanding the role of non-structural proteins (NSPs) and their implication in long-term severe repercussions of SARS-CoV-2 infection is an important step in the understanding of severe disease symptoms.

NSPs aid the SARS-CoV-2 virus in establishing the replication and transcription complex (RTC) through endoplasmic reticulum (ER) hijacking and immune evasion.  RTC along with membrane rearrangement can cause organelle damage such as ER stress, changes to autophagy machinery, Golgi fragmentation, and lysosome membrane alteration. This is thought to play a leading role in some of the more severe symptoms of SARS-CoV-2 infection such as neuronal, lung, and other organ damage.

We can now offer our customers access to a range of NSP antibodies for use in their COVID-19 research.

Catalog number Target Immunogen Cat no. Domain
29287-1-AP SARS-COV-2 NSP1 Polyclonal antibody Ag30935 1-180aa
29286-1-AP SARS-COV-2 NSP5 Polyclonal antibody Ag30934 1-306aa
29263-1-AP SARS-COV-2 NSP7 Polyclonal antibody Ag30933 1-83aa
29262-1-AP SARS-COV-2 NSP8 Polyclonal antibody Ag30932 1-198aa
29264-1-AP SARS-COV-2 NSP12 Polyclonal antibody Ag30931 1-200aa
29467-1-AP SARS-COV-2 NSP13 Polyclonal antibody Ag30930 318-469aa
29301-1-AP SARS-COV-2 NSP15 Polyclonal antibody Ag30929 1-346aa
Click here to browse all COVID-19 related products

 

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Posted:
27 July, 2021

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