Notable Publications - January 2017

A small selection of notable publications from January 2017.


What matters to Proteintech is the success of its antibodies in the hands of scientists.

Here’s just a small selection of publications from January 2017.

Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.

Nature Medicine (2017)

Institution:  Childhood Cancer Research Unit, Karolinska Institutet

Country: Sweden

Cited Product: SAMHD1 Rabbit PolyAb

PubMed ID: 28067901

Product Focus: SAMHD1
KD/KO Validated
Catalog number: 12586-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC, IF, FC
Publications 22

Reference: Herold N, Schaller T, et al. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies. Nature Medicine; 09 January 2017

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23.

Nature Communication (2017)

Institution:  State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, Nanjing University

Country: China

Cited product:  PKM1-specific Rabbit Polyclonal

Product Focus: PKM1-Specific Antibody
KD/KO Validated
Catalog number: 15821-1-AP
Type: Rabbit polyclonal
Applications: ELISA, WB, IP, IHC, IF
Publications: 20

Abstract:

Tumour cells secrete exosomes that are involved in the remodelling of the tumour–stromal environment and promoting malignancy. The mechanisms governing tumour exosome release, however, remain incompletely understood. Here we show that tumour cell exosomes secretion is controlled by pyruvate kinase type M2 (PKM2), which is upregulated and phosphorylated in tumours. Continue reading...

 

Reference: Yao Wei, Gang Hu et al. Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nature Comms; 09 January 2017

Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series.

Acta Neuropathologica (2017)

Institution:  Department of Neurology, Toyama University Hospital

Country:  Japan

Cited products:  TARDBP Rabbit PolyAb

Product Focus: TDP-43 Antibody
Catalog number: 10782-2-AP
Type: Rabbit Polyclonal
Applications: ELISA, WB, RIP, IP, IHC, IF, FC, CoIP, ChIP
Publications: 774

Reference: : Koji Yoshida, Naoki Nishida et al. Incipient progressive supranuclear palsy is more common than expected and may comprise clinicopathological subtypes: a forensic autopsy series. Acta Neuropathol; 07 January 2017.

Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity.

Nature Communication (2017)

Institution:  Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University

Country:  France

Cited product: GAPDH Mouse monoclonal

Product Focus: GAPDH
Catalog number: 60004-1-Ig 
Type: Mouse monoclonal
Applications: ELISA, WB, IP, IHC, IF, FC
Publications:  398

Abstract:

Monolayered epithelia are composed of tight cell assemblies that ensure polarized exchanges. EpCAM, an unconventional epithelial-specific cell adhesion molecule, is assumed to modulate epithelial morphogenesis in animal models, but little is known regarding its cellular functions. Inspired by the characterization of cellular defects in a rare EpCAM-related human intestinal disease, we find that the absence of EpCAM in enterocytes results in an aberrant apical domain. Continue Reading...

Reference: Julie Salomon, Delphine Delacouret al. Contractile forces at tricellular contacts modulate epithelial organization and monolayer integrity. Nature Communication; 13 Jan 2017

Company News

Posted:
1 February, 2017

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