FITC Anti-Mouse Foxp3 (3G3)
Foxp3 Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1
Reactivity
Mouse
Applications
FC
Conjugate
FITC Fluorescent Dye
CloneNo.
3G3
Cat no : FITC-65089
Synonyms
Validation Data Gallery
Tested Applications
Positive FC detected in | mouse splenocytes |
Recommended dilution
Application | Dilution |
---|---|
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Sample-dependent, Check data in validation data gallery. |
Product Information
FITC-65089 targets Foxp3 in FC applications and shows reactivity with Mouse samples.
Tested Reactivity | Mouse |
Host / Isotype | Mouse / IgG1 |
Class | Monoclonal |
Type | Antibody |
Immunogen | N/A |
Full Name | forkhead box P3 |
GenBank Accession Number | BC132333 |
Gene Symbol | Foxp3 |
Gene ID (NCBI) | 20371 |
RRID | AB_2883771 |
Conjugate | FITC Fluorescent Dye |
Excitation/Emission Maxima Wavelengths | 494 nm / 520 nm |
Form | Liquid |
Purification Method | Affinity purification |
Storage Buffer | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
Storage Conditions | Store at 2-8°C. Avoid exposure to light. |
Background Information
Foxp3 (forkhead box P3), also named as IPEX, JM2 and scurfin, is a member of the forkhead transcription factor family and is essential for normal immune homeostasis (PMID: 11138001; 20429413). Foxp3 is specifically expressed in CD4+ CD25+ regulatory T cells and is crucial for their development and suppressive activity (PMID: 12612578; 12612581). In scurfy mouse, disruption of Foxp3 results in the fatal lymphoproliferative disorder attributed to the lack of an immune-suppressive component in the immune system (PMID: 25683611; 11138001). Similar to mice, genetic defects in human Foxp3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) which also known as X-linked autoimmunity-immunodeficiency syndrome (PMID: 11137993).
Protocols
Product Specific Protocols | |
---|---|
FC protocol for FITC Foxp3 antibody FITC-65089 | Download protocol |
Standard Protocols | |
---|---|
Click here to view our Standard Protocols |