CD3 Antibody 1 Publications

Mouse Monoclonal| Catalog number: 60181-1-Ig |CloneNo.: 3F3A1

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Freight/Packing

Con: 105 μg/150 μl

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Species specificity:
human

Positive WB detected in:
Jurkat cells

Positive IHC detected in:
human tonsillitis tissue

Positive IF detected in:
human tonsillitis tissue

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:2000-1:20000
IHC : 1:100-1:400
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Caprylic acid/ammonium sulfate precipitation

Isotype:
IgG2b

Storage:
PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
CD3e molecule, epsilon (CD3-TCR complex)

Calculated molecular weight:
207aa,23 kDa

Observed molecular weight:
23 kDa

GenBank accession number:

Gene ID (NCBI):

Gene symbol
CD3E

Synonyms
CD3, CD3 epsilon, CD3E, CD3-epsilon, T3E, TCRE
Background

CD3 is a complex of proteins that directly associates with the T cell receptor (TCR). The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction. CD3 is considered to be a pan-T cell marker for detection of normal and neoplastic T cells. This anti-CD3 is a monoclonal antibody directed against the epsilon chain of human CD3 molecule.


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