CoraLite®594-conjugated CD206 Monoclonal antibody
CD206 Monoclonal Antibody for IF
Host / Isotype
Mouse / IgG2a
Reactivity
human
Applications
IF
Conjugate
CoraLite®594 Fluorescent Dye
CloneNo.
2A6A10
Cat no : CL594-60143
Synonyms
Validation Data Gallery
Tested Applications
Positive IF detected in | human lung cancer tissue |
Recommended dilution
Application | Dilution |
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Immunofluorescence (IF) | IF : 1:50-1:500 |
Sample-dependent, check data in validation data gallery |
Product Information
CL594-60143 targets CD206 in IF applications and shows reactivity with human samples.
Tested Reactivity | human |
Host / Isotype | Mouse / IgG2a |
Class | Monoclonal |
Type | Antibody |
Immunogen | Peptide |
Full Name | mannose receptor, C type 1 |
Calculated molecular weight | 166 kDa |
GenBank accession number | NM_002438 |
Gene symbol | MRC1 |
Gene ID (NCBI) | 4360 |
Conjugate | CoraLite®594 Fluorescent Dye |
Excitation/Emission maxima wavelengths | 588 nm / 604 nm |
Form | Liquid |
Purification Method | Protein A purification |
Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. |
Background Information
CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody is CL594(Ex/Em 593 nm/614 nm) conjugated.
Protocols
Product Specific Protocols | |
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IF protocol for CL594 CD206 antibody CL594-60143 | Download protocol |
Standard Protocols | |
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Click here to view our Standard Protocols |