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OLDS' NEWS

Showcasing the latest science news stories

'OLDS' NEWS' is a weekly roundup of the most interesting science and technology news stories from around the world. Each week Dr William Olds, Proteintech scientific officer, showcases current news stories keeping you in the loop with the latest industry updates.

Olds News archive - click the dates below to navigate
2019     
January February March April May June 2018
July August September October November December 2017

Week beginning May 25

  1. Think outside the antibodies - Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

  2. Where stress is stored - Hippocampal seed connectome-based modeling predicts the feeling of stress   

  3. The poor are always hit hardest - When hard data are ‘heartbreaking’: Testing blitz in San Francisco shows Covid-19 struck mostly low-wage workers

Week beginning May 18

  1. Vaccines so hot right now - Immunogenicity of a DNA vaccine candidate for COVID-19

  2. So basically what we can't do right now - Association between real-world experiential diversity and positive affect relates to hippocampal–striatal functional connectivity.

  3. Penguin guano and laughing gas - Combined effects of glacial retreat and penguin activity on soil greenhouse gas fluxes on South Georgia, sub-Antarctica

Week beginning May 11

  1. Oh no, our beloved meme animal! - Transmission of SARS-CoV-2 in Domestic Cats

  2. More testing coming up -  LabCorp, Quest broaden availability of COVID-19 tests nationwide

  3. The Ab tests on the market - EUA Authorized Serology Test Performance

Week beginning May 4

  1. What does this mean for Batman? - Bats really do harbor more dangerous viruses than other species

  2. Good proof of concept - A human monoclonal antibody blocking SARS-CoV-2 infection

  3. Pfizer approves - Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

Week beginning April 27

  1. ACE2's second wind - SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues

  2. No-cal sweeteners aren't fooling your brain - The gut–brain axis mediates sugar preference

  3. Remdesivir steps up to the plate - Critical study of Gilead’s Covid-19 drug shows patients are responding to treatment, NIH says

Week beginning April 20

  1. Is Dracula okay with GMOs? - Expanding the genetic code of the human hematopoietic system

  2. Changing destination - Scientists explore using CAR-T and other engineered immune cells to target COVID-19

  3. The Nose knows - Comparison of nasopharyngeal and oropharyngeal swabs for SARS-CoV-2 detection in 353 patients received tests with both specimens simultaneously

Week beginning April 13

  1. 2019: things aren't so bad | 2020: Yes, please! - Earth-Size, Habitable Zone Planet Found Hidden in Early NASA Kepler Data

  2. Plantibodies - A Broad and Potent H1-Specific Human Monoclonal Antibody Produced in Plants Prevents Influenza Virus Infection and Transmission in Guinea Pigs 

  3. Switching teams - Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

Week beginning April 6

  1. Sight and Flavortown - Functions of Opsins in Drosophila Taste

  2. Say "Cheese!" - Facial expressions of emotion states and their neuronal correlates in mice

  3. A Hard "Cell" - Textured soy protein scaffolds enable the generation of three-dimensional bovine skeletal muscle tissue for cell-based meat

Week beginning March 30

  1. Mental Stenographer - Machine translation of cortical activity to text with an encoder–decoder framework

  2. Why COVID19 figures are all over the place - Why It’s So Freaking Hard To Make A Good COVID-19 Model

  3. You can stop aging by using this one weird trick - Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells

Week beginning March 22

  1. The keys to the CAR-M's - Human chimeric antigen receptor macrophages for cancer immunotherapy 

  2. Blonde hair corelates with late puberty - Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

  3. Step in the right direction - Association of Daily Step Count and Step Intensity With Mortality Among US Adults

Week beginning March 16

  1. The most important meal of the day - Breakfast consumption and the risk of depressive symptoms: The Furukawa Nutrition and Health Study

  2. Messages from the grave - Metabolites released from apoptotic cells act as tissue messengers

  3. Building social solidarity - Shifting attributions for poverty motivates opposition to inequality and enhances egalitarianism

Week beginning March 9

  1. Your DNA is worth more than $95, folks - Evolving public views on the value of one’s DNA and expectations for genomic database governance: Results from a national survey

  2. Scorpion venom CAR-T cells - Chlorotoxin-directed CAR T cells for specific and effective targeting of glioblastoma

  3. The shape of memory - Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence in Drosophila

Week beginning March 2

  1. A new hangover cure! - Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms

  2. Eat less, live longer - Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

  3. Does it come in gummy form? - Novel technology for storage and distribution of live vaccines and other biological medicines at ambient temperature

Week beginning February 24

  1. LEGO HPLC kit - LEGO MINDSTORMS Fraction Collector: A Low-Cost Tool for a Preparative High-Performance Liquid Chromatography System

  2. Let’s break the cycle - Victims, perpetrators, or both? The vicious cycle of disrespect and cynical beliefs about human nature.

  3. What about oatmilk? - Dairy, soy, and risk of breast cancer: those confounded milks

Week beginning February 17

  1. Mastering "Parentese" - Parent coaching increases conversational turns and advances infant language development

  2. Change your eating, change your mind - Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet  

  3. Henry the 8th was very unlucky - No genetic contribution to variation in human offspring sex ratio: a total population study of 4.7 million births   

Week beginning February 10

  1. I love everything about this article - The physics of tossing fried rice

  2. Not what you would hope for - Latest White House Budget Features A Few Big Research Priorities Amid Ranging Reductions

  3. And 80% of senior PI's time is in meetings! - Three-quarters of researchers say yes to meeting-free weeks

Week beginning February 3

  1. Your dance-print, please - Dance to your own drum: Identification of musical genre and individual dancer from motion capture using machine learning

  2. Bee Movie 2: Tokyo Drift - Engineered symbionts activate honey bee immunity and limit pathogens

  3. Elon Musk approves - A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol

Week beginning January 27

  1. Don't just read the title - Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue

  2. Need a hand? - Multiplex CRISPR/Cas screen in regenerating haploid limbs of chimeric Axolotls

  3. Ooh it changes color! - Colorimetric Band-aids for Point-of-Care Sensing and Treating Bacterial Infection

Week beginning January 20

  1. Is it rational to be reasonable? - Folk standards of sound judgment: Rationality Versus Reasonableness

  2. East Coast blames West Coast - Evidence for impacts on surface-level air quality in the northeastern US from long-distance transport of smoke from North American fires during the Long Island Sound Tropospheric Ozone Study (LISTOS) 2018

  3. Flu vaccinations cut hospitalization in half - Influenza Vaccine Effectiveness Against Hospitalization in Fully and Partially Vaccinated Children in Israel: 2015–2016, 2016–2017, and 2017–2018

Week beginning January 13

  1. Tips for your Tinder account - Humans judge faces in incomplete photographs as physically more attractive

  2. Sugar laughs maniacally - Sucrose intake lowers μ-opioid and dopamine D2/3 receptor availability in porcine brain

  3. *Greta Thunberg stare* - Record-Setting Ocean Warmth Continued in 2019

Week beginning January 6

  1. Vitamin Tea - Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project

  2. That's KRAS-y! - Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

  3. Now more than ever - Understanding and countering the motivated roots of climate change denial

Week beginning December 30 - Happy New Year!

  1. Empathy is, unfortunately, not the solution - How Empathic Concern Fuels Political Polarization

  2. How are there 2500 spoken languages? - Emotion semantics show both cultural variation and universal structure

  3. Swipe left - Hook, Line and Sinker: Do Tinder Matches and Meet Ups Lead to One-Night Stands?

Week beginning December 16

  1. One man's corn is another's Chanel No. 5 - Consolidated production of coniferol and other high-value aromatic alcohols directly from lignocellulosic biomass  

  2. The follow-up better be Dino DNA from mosquitoes trapped in amber - A 5700 year-old human genome and oral microbiome from chewed birch pitch

  3. Guys, just be excellent to each other - Unprofessional peer reviews disproportionately harm underrepresented groups in STEM

Week beginning December 9

  1. No more midnight runs to Taco Bell - Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

  2. IoT meet DoT - A DNA-of-things storage architecture to create materials with embedded memory

  3. OK, Boomer - Longitudinal changes and historic differences in narcissism from adolescence to older adulthood.

Week beginning December 2

  1. Finding pleasure again - Serotonergic plasticity in the dorsal raphe nucleus characterizes susceptibility and resilience to anhedonia

  2. From pollution back into fuel - Conversion of Escherichia coli to Generate All Biomass Carbon from CO2

  3. More than you ever wanted to know - Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling

Week beginning November 18

  1. A strong Ig Nobel contender - Viscoelastic solid-repellent coatings for extreme water saving and global sanitation

  2. Making things worse - The mutational footprints of cancer therapies

  3. Is the developer Aperture Science? - Trash talk hurts, even when it comes from a robot

Week beginning November 11

  1. Titrating CRISPR-driven gene expression - Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery

  2. Drive slow, homie - The effects of musical auditory stimulation on heart rate autonomic responses to driving: A prospective randomized case-control pilot study

  3. Putting clean energy on the map - Climate and health benefits of increasing renewable energy deployment in the United States

Week beginning November 4

  1. The fruits of our labor-atory - Resequencing of 414 cultivated and wild watermelon accessions identifies selection for fruit quality traits  

  2. Making memory cells forget - Measles virus infection diminishes preexisting antibodies that offer protection from other pathogens

  3. Tension is rising - Vast Dragnet Targets Theft of Biomedical Secrets for China

Week beginning October 28

  1. A blight idea - Broad-spectrum resistance to bacterial blight in rice using genome editing

  2. Eat well to fight climate change - Multiple health and environmental impacts of foods

  3. Shortcuts for circuits - High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing

Week beginning October 21

  1. Press X to doubt - Socially transmitted placebo effects

  2. The rain in Spain falls mainly in the plain - Evidence for the reproduction of social class in brief speech

  3. ANTi-Traffic - Experimental investigation of ant traffic under crowded conditions

Week beginning October 14

  1. Don’t get too excited - Regulation of lifespan by neural excitation and REST

  2. Reducing cost at a cost - Pelosi drug plan would save $370B, but could reduce R&D, forecasters say

  3. Don’t be so negative - Cross-national evidence of a negativity bias in psychophysiological reactions to news

Week beginning October 7

  1. One for the LA folks - Simple parking strategies

  2. One man's waste is another man's treasure - Social, demographic, and economic correlates of food and chemical consumption measured by wastewater-based epidemiology

  3. Having a dog is good for your heart - Pet Ownership and Cardiovascular Risk

Week beginning September 30

  1. 2019: even relaxation causes anxiety - The paradox of relaxation training: Relaxation induced anxiety and mediation effects of negative contrast sensitivity in generalized anxiety disorder and major depressive disorder

  2. The final frontier - Targeted isolation and cultivation of uncultivated bacteria by reverse genomics

  3. Brexitis - Acute transient psychotic disorder precipitated by Brexit vote

Week beginning September 23

  1. And the IgNobel goes to… - Does pizza protect against cancer?

  2. The ‘9 to 5’ T cells - The circadian clock of CD8 T cells modulates their early response to vaccination and the rhythmicity of related signaling pathways

  3. MARCM clones for mice - Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

Week beginning September 16

  1. Brain Doping - Activity in the dorsal ACC causes deterioration of sequential motor performance due to anxiety

  2. Not great, Bob! - Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

  3. More trains = less traffic - Critical factors for mitigating car traffic in cities

Week beginning September 9

  1. Amyloid is good? - Amyloid-like Assembly Activates a Phosphatase in the Developing Drosophila Embryo

  2. Building the ‘AAlphabet’ - Adaptive Properties of the Genetically Encoded Amino Acid Alphabet Are Inherited from Its Subsets

  3. Immune system continues its run - Lasker Awards Honor Advances in Modern Immunology

Week beginning September 2

  1. Mendel's peas finally sequenced - A reference genome for pea provides insight into legume genome evolution

  2. A rose by any other name - Color Categorization Independent of Color Naming

  3. In the 'palmitoyl' of cancer's hands - Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation

Week beginning August 26 

  1. DNA is going to be so ‘gelly’ - Programmable CRISPR-responsive smart materials

  2. Striking the right ‘ketone’ - Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

  3. Tropical tropism - Precision mouse models with expanded tropism for human pathogens

Week beginning August 19 

  1. Twitter anti-venom - Visitors to urban greenspace have higher sentiment and lower negativity on Twitter

  2. Black Schwann - Specialized cutaneous Schwann cells initiate pain sensation

  3. CD24 joins the I/O club - CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

Week beginning August 12

  1. Hitchcockian dystopia – Are e-scooters polluters? The environmental impacts of shared dockless electric scooters

  2. Ready for prime time - CRISPR enters its first human clinical trials

  3. Not Just Elizabeth Holmes - The Theranos Effect: When Cutting-Edge Scientists Are Frauds

Week beginning August 5 

  1. Pizza rat could do more than carry pizza slices - Laboratory mice born to wild mice have natural microbiota and model human immune responses

  2. Don't believe your eyes - Causal Evidence for Expression of Perceptual Expectations in Category-Selective Extrastriate Regions

  3. Turing Test 2.0 - Trick Me If You Can: Human-in-the-Loop Generation of Adversarial Examples for Question Answering

Week beginning July 29 

  1. Good for everything - T cell–mediated regulation of the microbiota protects against obesity

  2. Good enough - The two-year deal sets up science agencies for moderate funding increases in FY 2020, followed by a tougher year in FY 2021, after which the spending caps expire

  3. Good for something - Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Week beginning July 22

  1. You are WHEN you eat - Early Time‐Restricted Feeding Reduces Appetite and Increases Fat Oxidation But Does Not Affect Energy Expenditure in Humans

  2. Nth time’s the charm? - The Senate takes a bipartisan swing at drug price reform. Can it connect?

  3. Blame ancient humans - Human species-specific loss of CMP-N-acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms

Week beginning July 15

  1. C-3PO getting swoll - Sheath-run artificial muscles

  2. Before it was cool - Deep hydrous mantle reservoir provides evidence for crustal recycling before 3.3 billion years ago

  3. Justifying my hours of Super Mario - Quantity and quality of mental activities and the risk of incident mild cognitive impairment

Week beginning July 8 

  1. Thanos >>> - The Gordian Knot of Disposition Theory: Character Morality and Liking

  2. Changing Climate Change studies - Agriculture Department buries studies showing dangers of climate change

  3. No biggie - Breeding crops to feed 10 billion

Week beginning June 24 

  1. The Borg neurons - Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

  2. By 'golli'! - Identification of a novel variant of Golli myelin basic protein BG21 in the uniquely neuroprotective white-footed mouse

  3. Drive it like you stole it - Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding 

Week beginning June 17

  1. Another 3D Printer I can’t afford - Individual cell-only bioink and photocurable supporting medium for 3D printing and generation of engineered tissues with complex geometries

  2. Talking with their eyebrows - Evolution of facial muscle anatomy in dogs

  3. Snail beats Gorilla Glue - Intrinsically reversible superglues via shape adaptation inspired by snail epiphragm

Week beginning June 10

  1. Peter Parker's been scooped - Toward Spider Glue: Long Read Scaffolding for Extreme Length and Repetitious Silk Family Genes AgSp1 and AgSp2 with Insights into Functional Adaptation

  2. Science for all - The war to free science

  3. A Scrooge McDuck Vault - How will we pay for the coming generation of potentially curative gene therapies?

Week beginning June 3 

  1. FBI searches microbiome - The FBI Searched the Offices of Microbiome Startup uBiome

  2. Sponsored by your local dentist - Porphyromonas gingivalis in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

  3. A technical foul - To catch and reverse a quantum jump mid-flight

Week beginning May 27 

  1. Fat makes you less stressed - Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience properties

  2. Ugh…Maybe not - A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling

  3. Maybe this will make you feel better - Humans adapt to social diversity over time

Week beginning May 20

  1. "I did this" meme - MIT professor is accused of claiming others’ scientific discoveries as his own

  2. Tetra-CYCLING - Merck boosts late-phase cancer pipeline with $1.1B Peloton buy

  3. Going for the head - A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

Week beginning May 13

  1. Life in plastic, not fantastic - Plastic leachates impair growth and oxygen production in Prochlorococcus, the ocean’s most abundant photosynthetic bacteria

  2. A challenger approaches - Second Place America? Increasing Challenges to U.S. Scientific Leadership: 2019 Benchmarks

  3. The enemy of good - Perfectionism is increasing over time: A meta-analysis of birth cohort differences from 1989 to 2016

Week beginning May 6 

  1. Neural Pokedex - A Pokémon-sized window into the human brain  

  2. Replicating reproducibility – Reproducibility and Replicability in Science

  3. Beer Physics - Bubble cascade in Guinness beer is caused by gravity current instability

Week beginning April 29 

  1. Trumping Anti-Vaxxers - ‘They have to get the shots’: Trump, once a vaccine skeptic, changes his tune amid measles outbreaks

  2. Chickpea-Fil-A - Resequencing of 429 chickpea accessions from 45 countries provides insights into genome diversity, domestication and agronomic traits

  3. Time is all relative...to eating - Insulin/IGF-1 Drives PERIOD Synthesis to Entrain Circadian Rhythms with Feeding Time

Week beginning April 22

  1. A plastic straw comeback? - Closed-loop recycling of plastics enabled by dynamic covalent diketoenamine bonds

  2. Humans get CRISPR - First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

  3. Anxiety from cortex depends on context - Regional cortical thickness and neuroticism across the lifespan

Week beginning April 15

  1. Tackling the Tide Pod Challenge - A values-alignment intervention protects adolescents from the effects of food marketing

  2. Next on the box of Wheaties - Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine

  3. I chose the wrong field - The age at which Noble Prize research is conducted

Week beginning April 8

  1. Anti-Hannibal molecule - Small peptide–mediated self-recognition prevents cannibalism in predatory nematodes

  2. An eye for an eye - This clinic’s experimental stem cell treatment blinded patients. Years later, the government is still trying to stop it.

  3. Not so gluten-free - Detection of Gluten in Gluten-Free Labeled Restaurant Food

Week beginning April 1

  1. Can Bose make mental noise-canceling headphones? - Neuroticism as mental noise: Evidence from a continuous tracking task

  2. It takes guts - Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5−/− mice

  3. Phase transition - Early studies hint at some potential for CAR-T therapy in solid tumors

Week beginning March 25 

  1. Sugar high tumors - High-fructose corn syrup enhances intestinal tumor growth in mice

  2. Process Error - A Hallucinogenic Serotonin-2A Receptor Agonist Reduces Visual Response Gain and Alters Temporal Dynamics in Mouse V1

  3. NEJM's views on Plan S - No Free Lunch — What Price Plan S for Scientific Publishing?  

Week beginning March 18

  1. Getting immune cells to snitch on cancer - Engineered immune cells as highly sensitive cancer diagnostics

  2. Eternal sunshine - Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans

  3. Hopeful for an e day, too - Foster Introduces Pi Day Resolution

Week beginning March 11

  1. Vitamin D testing at the barbershop? - 25-Hydroxyvitamin D Measurement in Human Hair: Results from a Proof-of-Concept study

  2. I like the ultrasounds of that - Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation

  3. Cue the Jurassic Park theme - Signs of biological activities of 28,000-year-old mammoth nuclei in mouse oocytes visualized by live-cell imaging

Week beginning March 4

  1. Cancer's AirBnB - Hepatocytes direct the formation of a pro-metastatic niche in the liver

  2. Gottlieb's gotten out - Scott Gottlieb Resigns as Commissioner of the F.D.A.

  3. Throwing shade - Hybrid dynamic windows using reversible metal electrodeposition and ion insertion

Week beginning February 25 

  1. The sweet smell of memory - Odor-evoked category reactivation in human ventromedial prefrontal cortex during sleep promotes memory consolidation

  2. Killing the bug's bug - Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission

  3. Add a little stress to your diet - Activation of Anxiogenic Circuits Instigates Resistance to Diet-Induced Obesity via Increased Energy Expenditure

Week beginning February 18 2019

  1. Flesh-eating bacteria, not just for supervillains - Integrated analysis of population genomics, transcriptomics and virulence provides novel insights into Streptococcus pyogenes pathogenesis

  2. Superman's disguise is now scientifically accurate - Deliberate disguise in face identification.

  3. Destruction and construction - Large teams develop and small teams disrupt science and technology

Week beginning February 11 2019

  1. OK Computer - Executive Order on Maintaining American Leadership in Artificial Intelligence

  2. In Search of Lost Memory T Cells - Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells

  3. Gone the Way of the Dodo - What happened to bird flu? How a major threat to human health faded from view

Week beginning February 4 2019

  1. Sleep your way to better health! - A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila

  2. Antidepressant yogurt - The neuroactive potential of the human gut microbiota in quality of life and depression

  3. An argument for more women on the SCOTUS - Persistent metabolic youth in the aging female brain

Week beginning January 28 2019 

  1. More good news! - The Global Syndemic of Obesity, Undernutrition, and Climate Change: The Lancet Commission report

  2. The horn is glued on… - Stealth research: lack of peer‐reviewed evidence from healthcare unicorns

  3. Just in time for Valentine’s Day - A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

Week beginning January 21 2019

  1. Guccifer 3.0? – U.S. Officials Warn Health Researchers: China May Be Trying to Steal Your Data

  2. Ahead of the curve - Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

  3. Just in time for me to quit the gym - CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency

Week beginning January 7 2019

  1. Hot tomato, Hot tomato - Capsaicinoids: Pungency beyond Capsicum

  2. Biotechnology and mitigating forest disaster - Biotechnology Holds Promise for Protecting Forest Health, But Investments in Research Are Needed, Along With Public Dialogue

  3. Even computers make guesses - The need for uncertainty quantification in machine-assisted medical decision making

Week beginning December 31 2018 - Happy new year!

  1. Alexa, play genomics - A primer on deep learning in genomics.

  2. Throw away the chocolate in your stocking - Glucose-Induced β-Catenin Acetylation Enhances Wnt Signaling in Cancer.

  3. SELLgene - Bristol-Myers to buy Celgene in industry-shaking $74B deal.

Week beginning December 17 - Deck the halls edition

  1. Deck the organoids with bells of T cells - Organoid Modeling of the Tumor Immune Microenvironment

  2. Fa la la HLA HLA - Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification

  3. Don we now our Paris Agreement - Climate Negotiators Reach an Overtime Deal to Keep Paris Pact Alive

Week beginning December 10

  1. Cultured meat’s back on the menu - Statement from USDA Secretary Perdue and FDA Commissioner Gottlieb on the Regulation of Cell-Cultured Food Products from Cell Lines of Livestock and Poultry

  2. Allen Institute Immune Booster - With a gift from the late Paul Allen, his philanthropy launches ambitious plan to probe human immunology

  3. Engram telegram  - Engram Cell Excitability State Determines the Efficacy of Memory Retrieval

Week beginning November 26

  1. No one can serve two masters - Memorial Sloan Kettering scandal raises questions for pharma's biggest corporate boards

  2. From disagreement to ‘Fake News!’ - Scientific polarization

  3. Designer Genie is out of the bottle- China’s gene-edited babies will push bioethics into a dark new era

Week beginning November 19

  1. Brown fat stopped you from that extra turkey leg - Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

  2. What T cells want - T cell receptor fingerprinting enables in-depth characterization of the interactions governing recognition of peptide–MHC complexes

  3. Following in Rembrandt’s footsteps - Quantifying reputation and success in art

Week beginning November 12

  1. Think happy thoughts at the dentist - Behavioural and neural evidence for self-reinforcing expectancy effects on pain

  2. Multitasking unitasking for better performance - The Illusion of Multitasking and Its Positive Effect on Performance

  3. Next generation ‘mood rings’ coming soon?- An Amygdala-Hippocampus Subnetwork that Encodes Variation in Human Mood

Week beginning October 29

  1. So...intelligent design then? - Currently available bulk sequencing data do not necessarily support a model of neutral tumor evolution

  2. Space Force, Assemble! - Plans for Space Force Laid Out at National Space Council Meeting

  3. Microbial culture shock - US Immigration Westernizes the Human Gut Microbiome

Week beginning October 22nd

  1. 'Now that's the last (plastic) straw!' - Macro- and microplastics affect cold-water corals growth, feeding and behaviour

  2. Brain Trust - Backed by Bain, Pfizer loads prime CNS assets into new biotech

  3. Inflaming heart - Grief, Depressive Symptoms, and Inflammation in the Spousally Bereaved

Week beginning October 15th

  1. Yikes! - Why Can Only 24% Solve Bayesian Reasoning Problems in Natural Frequencies: Frequency Phobia in Spite of Probability Blindness

  2. Insulin on trial - Minnesota takes aim at Sanofi, Novo, Lilly for insulin prices

  3. Throw away the nicotine gum - An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse

Week beginning October 8th

  1. Fasting a fast way to help Diabetics? - Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin

  2. Add RNA viruses to your Tinder profile? - Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans

  3. May want to check your toothpaste ingredients - A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice

Week beginning October 1st

  1. ‘I’ll be back’ - Rise of the Machines: Artificial Intelligence and its Growing Impact on U.S. Policy (Subcommittee on Oversight and Government Reform, House of Representatives)

  2. From germ to cure - Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice

  3. Long-tenured NEJM editor retires - New England Journal of Medicine’s longtime editor to retire

Week beginning September 24th

  1. Let me count the ways - Single Neurons in the Human Brain Encode Numbers

  2. There's an app for that - Smartphone Nanocolorimetry for On-Demand Lead Detection and Quantitation in Drinking Water

  3. Muscle’s Origin - Identification of the Human Skeletal Stem Cell

Week beginning September 17th

  1. Pushing the nuclear envelope - House Approves Bill to Maintain America’s Leadership in Nuclear Technology

  2. Big headache for Aspirin - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

  3. Crooked scheme alleged for Abbvie - AbbVie accused of 'far-reaching' kickback scheme for Humira

Week beginning September 10th

1. Please accelerate this clinical trial - Deciduous autologous tooth stem cells regenerate dental pulp after implantation into injured teeth

2. CRISPR toast for UC Berkeley - The battle over CRISPR patents come to a close.

3. Siberian Bear microbiota - Ultra high-throughput functional profiling of microbiota communities

Week beginning September 3rd

1. Fall of the Berlin Paywall - EU and national funders launch plan for free and immediate open access to journals.

2. At your zinc fingertips - Sangamo Announces 16 Week Clinical Results Including Reductions In Glycosaminoglycans In Phase 1/2 Trial Evaluating SB-913, A Zinc Finger Nuclease Genome Editing Treatment for MPS II (Hunter Syndrome)

3. Hopefully the move makes more money - Theranos Cost Business and Government Leaders More Than $600 Million

Week beginning August 27th

1. Baby’s first immune system - Stereotypic Immune System Development in Newborn Children

2. Mass beats Cal - MassBio: Massachusetts dominates IPO market, VC funding in 2017

3. Beer is no superfood - Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Week beginning August 20th

  1. When should I toss away that Rx? - Can You Take Expired Drugs?

  2. Rethinking psychedelics - ‘Microdosing’ is touted by ’shroomers and Reddit users. Science is starting to test their claims — and finding some truth

  3. Breaking leptin’s silence  - Cleavage of the leptin receptor by matrix metalloproteinase–2 promotes leptin resistance and obesity in mice

Week beginning August 13th

  1. Yay, more stuff to worry about! – Broad Institute, Mass General Team Develops Polygenic Risk Scores for Five Common Diseases

  2. Healthy Germs - Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

  3. Minding the wage gap - The Growing Executive-Physician Wage Gap in Major US Nonprofit Hospitals and Burden of Nonclinical Workers on the US Healthcare System

 Week beginning August 6th

  1. Microbes made easy! - Emergent simplicity in microbial community assembly

  2. Insider biotech trading - NY Rep. Collins arrested by FBI for insider trading in Australian biotech

  3. Examining racism in policing - Do White Law Enforcement Officers Target Minority Suspects?

Week beginning July 30th

  1. Making sense of missense - Predicting the clinical impact of human mutation with deep neural networks

  2. DNA Spellcheck Coming Soon? - NIH Commits Up to $45.5M to Fund Genome Editing Technology Projects

  3. ‘I call him Gamblor’ - Did a blockbuster drug make hundreds gamble compulsively? A legal fight may decide what science can’t confirm

Week beginning July 16th

  1. CRISPR feeling the burn - Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements  

  2. Parasite boosts nutrition of host - Cytokinin transfer by a free-living mirid to Nicotiana attenuata recapitulates a strategy of endophytic insects

  3. Allergies are finally good for something - Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

Week beginning July 9th

  1. Aussies can throw away bug spray - Trial wipes out more than 80 per cent of disease-spreading mozzie

  2. Yes, we cannabis - FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy

  3. Thinking is temperature-sensitive - Reduced cognitive function during a heat wave among residents of non-air-conditioned buildings: An observational study of young adults in the summer of 2016

Week beginning July 2nd

  1. GABA GABA DOO! - Structure of a human synaptic GABAA receptor

  2. Cut the chit-chat - “Eavesdropping on Happiness” Revisited: A Pooled, Multisample Replication of the Association Between Life Satisfaction and Observed Daily Conversation Quantity and Quality

  3. Crouching Tiger, Hidden Dragon - I-Mab closes one of China’s biggest-ever biotech fundraisings

Week beginning 25th June 2018

  1. Beer’s Law - A molecular mechanism for choosing alcohol over an alternative reward

  2. Cracking the ‘codon’ - Codon-specific translation reprogramming promotes resistance to targeted therapy

  3. GE shedding healthcare - GE to spin off healthcare unit in latest restructuring

Week beginning 11th June 2018

  1. Download the National Academies of Science, Engineering, and Medicine’s report on Sexual Harassment in STEM - Sexual Harassment of Women: Climate, Culture, and Consequences in Academic Sciences, Engineering, and Medicine

  2. Slowing the hype train for CRISPR - CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response

  3. ‘TRIM’-ming neurodegeneration - Depleting Trim28 in adult mice is well tolerated and reduces levels of α-synuclein and tau

Week beginning 4th June 2018

  1. Coffee, the teamwork catalyst - Coffee with co-workers: role of caffeine on evaluations of the self and others in group settings

  2. Safely forgoing chemo - Fewer Breast Cancer Patients Benefit From Chemo, TAILORx Study With Oncotype DX Finds

  3. Strong as an ‘auxin’ - Synthetic hormone-responsive transcription factors can monitor and re-program plant development

Week beginning 28th May 2018

  1. First artificial iris approved - FDA approves first artificial iris

  2. With a little help from my friends - A Larger Social Network Enhances Novel Object Location Memory and Reduces Hippocampal Microgliosis in Aged Mice

  3. What makes something delicious? - The coding of valence and identity in the mammalian taste system

Week beginning 21st May 2018

  1. Big price-tag for migraine drug - Amgen, Novartis' closely watched migraine drug approved

  2. Give this dog a bone - First bone-cracking dog coprolites provide new insight into bone consumption in Borophagus and their unique ecological niche

  3. ‘Right to Try’ bill closer to law - Congress passes ‘right-to-try’ measure, sending hard-fought bill to Trump’s desk

Week beginning 14th May 2018

  1. Thanks for the memories - RNA from Trained Aplysia Can Induce an Epigenetic Engram for Long-Term Sensitization in Untrained Aplysia

  2. The doctor will sequence you now - Genoox raises $6M to help physicians better diagnose patients with genomic data

  3. Wiki’s most cited journal articles - Analyzing DOI Citations in English Wikipedia

Week beginning 7th May 2018

  1. It pays to be small biotech - Small Biotech is much more efficient than large Pharma in developing new drugs.

  2. Going with your gut and your brain - Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans

  3. Keeping your DNA secret – Alternative models for sharing confidential biomedical data

Week beginning 30th April 2018

  1. One last gift from Stephen Hawking - A smooth exit from eternal inflation?

  2. Teaching (not so well) hospital? - The next generation of doctors may be learning bad habits at teaching hospitals with many safety violations

  3. FDA enhancing medical device safety -  New efforts to enhance and modernize the FDA’s approach to medical device safety and innovation

Week beginning 23rd April 2018

  1. Pharma donates probes - Science Forum: Donated chemical probes for open science

  2. A Myriad of Problems - Class Action Suits Against Myriad Allege Failure to Disclose Medicare Billing Practices to Investors

  3. Superman vision - Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

Week beginning 16th April 2018

  1. Now I remember -  Innate immune memory in the brain shapes neurological disease hallmarks

  2. Race and Empathy - Neurocognitive Basis of Racial Ingroup Bias in Empathy

  3. Skeleton Key-truda - Merck looks to catch Bristol with new melanoma data for Keytruda

Week beginning 2nd April 2018

  1. Impact of tariffs on medical products - Proposed China tariffs target dozens of medical products

  2. Splicing up cancer - Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Week beginning 26th March 2018

  1. Hunger “Pains” – A Neural Circuit for the Suppression of Pain by a Competing Need State

  2. One man’s trash is another man’s fuel source - Discovery of enzymes for toluene synthesis from anoxic microbial communities

  3. Gene-editing IPO - Homology lands $144M in an upsized IPO to advance gene-editing treatment

Week beginning 19th March 2018

  1. Big Bucks for NIH - U.S. spending deal contains largest research spending increase in a decade

  2. For those who don’t like change - Engineered promoters enable constant gene expression at any copy number in bacteria

  3. Aging brains like lysosomes - Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

Week beginning 12th March 2018

  1. Space changes DNA - NASA Twins Study Confirms Preliminary Findings

  2. Thera-WOES - SEC charges against Theranos, Holmes dispel last shreds of unicorn myth  

  3. Puzzling plants - Why plants make puzzle cells, and how their shape emerges

Week beginning 5th March 2018

  1. Freakishly fast fake news - The spread of true and false news online

  2. Embryo knows obesity - Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes

  3. Support scientists’ mental health - Evidence for a mental health crisis in graduate education

Week beginning 26th February 2018

  1. Skin care by S. epidermidis - A commensal strain of Staphylococcus epidermidis protects against skin neoplasia  

  2. Towards a better mood -Orphan receptor GPR158 controls stress-induced depression

  3. A good year for crop yields cause conflict? - Food Abundance and Violent Conflict in Africa

Week beginning 19th February 2018

  1. Webster’s Dictionary Defines ‘Research Excellence’ as… - Research excellence indicators: time to reimagine the ‘making of’?

  2. One step closer to Amazon Pharma - Amazon selling private-label medications

  3. Stretchy circuits on skin - Skin electronics from scalable fabrication of an intrinsically stretchable transistor array

Week beginning 12th February 2018

  1. Cryptocurrency for DNA -  George Church founds cryptocurrency-fueled genomics firm

  2. Optogenetics goes deeper into the brain - Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

  3. CRISPR! CRISPR! Read all about it – The CRISPR Journal inaugural issue published, with content from Rodolphe Barrangou, et al

Week beginning 5th February 2018

  1. No more insulin shots? - In diabetes war, Novo Nordisk aims to break mold with new pill

  2. Added sugars - Structure of the yeast oligosaccharyltransferase complex gives insight into eukaryotic N-glycosylation

  3. MMM…fructose - The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

Week beginning 29th January 2018 

  1. Sizing up Bezos-care - What to make of Amazon and Warren Buffett’s mystery health care project

  2. Understanding Serendipity - Serendipity: Towards a taxonomy and a theory

  3. Fizzy Chemistry - CO2 Diffusion in Various Carbonated Beverages: A Molecular Dynamics Study

Week beginning 22nd January 2018

  1. Breaking down Gene Editing Barriers - NIH to launch genome editing research program

  2. DNA Grows Muscles - A self-assembled nanoscale robotic arm controlled by electric fields

  3. Patience Is Key-truda - Keytruda aces another lung cancer study

Week beginning 15th January 2018

  1. CRISPRing to feed the world: Genome Editing for Global Food Security

  2. Microwaves cause MACRO harm: Environmental assessment of microwaves and the effect of European energy efficiency and waste management legislation

  3. How instability drives metastasis: Chromosomal instability drives metastasis through a cytosolic DNA response

Week beginning 8th January 

  1. Brain Drain: Pfizer pulls back from neuroscience, ending research

  2. Ultrasounding microbiome: Acoustic reporter genes for noninvasive imaging of microorganisms in mammalian host

  3. Baby steps for Human Gene Editing: First In Vivo Human Genome Editing to Be Tested in New Clinical Trial

OLDS News 2017 Review! 

Biggest AI Showdown:

Mastering the game of Go without human knowledge

It is an understatement to say that AI had a big year this year with its encroachment into transportation, cooking, and searching for planets. This ancient Chinese game is one of the essential arts of scholars. It is more complex than chess with more legal moves than atoms in the universe. Using deep learning software, this AI beat the number one player in the world, Ke Jie. Next year, it will be exciting to see how AI stops playing and starts working.

Biggest Biotech IPO:

Denali Therapeutics 

Denali Therapeutics wears the crown this year with $248 million raised for its IPO. Neurodegenerative diseases have eluded pharma for decades, but investors have a lot of confidence in Denali’s approach. Denali has one drug in phase 1 trials (DNL201), but the rest of its portfolio is in the pre-clinical stage. Denali will be a fascinating player to watch in 2018 and beyond. 

Biggest CRISPR Story:

CRISPR: Civil (Patent) War 

CRISPR is Biology’s Marvel Cinematic Universe with a bunch of heroes (RNA editor, tape recorder, epigenetic modifier, but it is the patent battle between Berkeley and the Broad Institute that is the most intriguing and has the most implications for the future applications of this technology. Broad Institute has won round 1 with the US Patent Office, but this battle is far from over.

Week beginning 27th November

  1. Okazaki Not So Fragmented -Precise Editing at DNA Replication Forks Enables Multiplex Genome Engineering in Eukaryotes

  2. Unnatural Made Natural - A semi-synthetic organism that stores and retrieves increased genetic information

  3. Fixing a Broken Heart - Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

week beginning 6th November

  1. Life was so much simpler back in my day … - America was Great When Nationally Relevant Events Occurred and When Americans Were Young

  2. Do animals think or react? - Rational Inference: The Lowest Bounds

  3. White House’s Opioid Crisis Commission Update - Here are the final recommendations of the White House opioid commission

Week beginning 23rd October

  1. Enhancing Postdoc Training Experience -  Point of View: What’s in a name

  2. Possible Directions for Bioscience Training -  Point of View: The future of graduate and postdoctoral training in the biosciences

  3. A Brief THESIS of Time -  Step inside the mind of the young Stephen Hawking as his PhD thesis goes online for first time

Week beginning 16th October

  1. Look, ma, no supervision! - Mastering the game of Go without human knowledge.

  2. Unlocking more potential of stem cells - Establishment of mouse expanded potential stem cells.  

  3. Front runners for the next White House drug czar - Next in line as Trump’s drug czar? Names of possible contenders start to circulate. 

Week beginning 2nd October 

  1. Neural autophagy may be key to life extension: Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans

  2. Pouring your heart out on the page lowers stress: The effect of expressive writing on the error-related negativity among individuals with chronic worry

  3. Evaporating energy prospects: Potential for natural evaporation as a reliable renewable energy resource

Week beginning 18th September

  1. Gut Bacteria Predict Efficacy of Dieting:   Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention

  2. $250 million more for 23andMe: 23andMe confirms $250 million round led by Sequoia

  3. Facebook for Proteins: Protein maps chart the causes of disease

Week beginning 4th September

  1. It’s All Greek to Me - The readability of scientific texts is decreasing over time

  2. Sketching Used to Detect Early Stage Parkinson’s - Distinguishing Different Stages of Parkinson’s Disease Using Composite Index of Speed and Pen-Pressure of Sketching a Spiral

  3. SNAP Money Is Not Enough for Affording Healthy Diet - The Affordability of MyPlate: An Analysis of SNAP Benefits and the Actual Cost of Eating According to the Dietary Guidelines

Week beginning 21st August

  1. The Puppeteers of PDL1 - 'Identification of CMTM6 and CMTM4 as PD-L1 protein regulators'.

  2. Long live killifish - 'Regulation of life span by the gut microbiota in the short-lived African turquoise killifish'.

  3. Faster Forensics- 'Rapid DNA Act Signed into Law'.

Week beginning 14th August

  1. The FDA’s accelerated approval program: How are drugs scoring in their “check-up”? - Characteristics of Preapproval and Postapproval Studies for Drugs Granted Accelerated Approval by the US Food and Drug Administration

  2. The brains behind the pig-human chimeras - The creator of the pig-human chimera keeps proving other scientists wrong

  3. A hope for hair loss - Lactate dehydrogenase activity drives hair follicle stem cell activation

Week beginning 7th August

  1. Correction of a pathogenic gene mutation in human embryos  http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html?foxtrotcallback=true

  2. There’s a Weird Relationship Between Cancer and Alzheimer’s  https://futurism.com/theres-a-weird-relationship-between-cancer-and-alzheimers/

  3. Humor norms for 4,997 English words  https://link.springer.com/article/10.3758/s13428-017-0930-6

Week beginning 17th July

  1. Industry News: Eli Lilly selling 2/3 of cancer pipeline  http://www.fiercebiotech.com/biotech/lilly-puts-two-thirds-mid-phase-cancer-pipeline-up-for-sale-major-shake-up-r-d-priorities

  2. Policy: Glimmer of hope in Dept of Energy research funding http://www.sciencemag.org/news/2017/07/unusual-candor-senate-appropriators-reject-cuts-energy-research

  3. Lights..Camera...CRISPR: Old-timey movie encoded into bacteria using CRISPR-Cas9 http://www.nature.com/nature/journal/v547/n7663/full/nature23017.html

Week beginning 10th July

  1. How FDA Plans to Help Consumers Capitalize on Advances in Science https://blogs.fda.gov/fdavoice/index.php/2017/07/how-fda-plans-to-help-consumers-capitalize-on-advances-in-science/

Week beginning 3rd July

  1. Of mice and men: A comparative analysis of human and mouse islet G-protein coupled receptor expression https://www.nature.com/articles/srep46600 

 

https://www.nature.com/articles/s41467-020-16256-y

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Posted:
29 August, 2019

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